Antibiotics Tied to Lower Effectiveness of Childhood Vaccines

Use of the drugs in children under the age of two was associated with lower antibody levels after the jabs—perhaps, researchers suggest, due to microbiome alterations.

Written byNatalia Mesa, PhD
| 2 min read
Baby face up in spotted onesie about to get an injection with a vaccine
Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

A study published yesterday (April 27) in Pediatrics finds that children who received a course of antibiotics during the first two years of life had diminished immune responses to four common vaccines. Researchers tell Science News that the findings are a cautionary tale about overusing antibiotics.

Babies are typically immunized against various diseases in the first six months of life and get boosters in their second year. From 2000 to 2016, the study’s authors collected blood samples from 560 children ages 6 to 24 months during routine visits with their pediatricians, measuring antibody levels after the children received polio, diphtheria-tetanus-pertussis, Haemophilus influenzae type b, and pneumococcal vaccines.

Of these children, 342 had collectively been prescribed close to 1,700 courses of antibiotics. The other 218 children had not received antibiotics. The team analyzed whether antibody levels induced by the four vaccines met the threshold of what is considered protective and found ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • A black and white headshot

    As she was completing her graduate thesis on the neuroscience of vision, Natalia found that she loved to talk to other people about how science impacts them. This passion led Natalia to take up writing and science communication, and she has contributed to outlets including Scientific American and the Broad Institute. Natalia completed her PhD in neuroscience at the University of Washington and graduated from Cornell University with a bachelor’s degree in biological sciences. She was previously an intern at The Scientist, and currently freelances from her home in Seattle. 

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH