Bile and Potatoes, 1921

One hundred years after its invention, BCG has stood the test of time as a vaccine against tuberculosis.

| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

ABOVE: Although the Bacille Calmette-Guérin (BCG) vaccine has never been routinely administered in the United States due to the country’s low incidence of tuberculosis, it is sometimes given to children who are regularly exposed to others with the disease. It was originally administered in an oral formulation, but researchers subsequently developed a version given as a shallow injection into the skin, shown here being administered by Reuben Erickson, the chief of the Division of Tuberculosis at Albany Hospital, in 1949.
CORNELL CAPA/THE LIFE PICTURE COLLECTION VIA GETTY IMAGES

In the early 20th century, French bacteriologists Albert Calmette and Camille Guérin at the Pasteur Institute in Lille set out to develop a vaccine to protect against tuberculosis, a potentially severe lung infection that has been responsible for more human deaths than any other pathogen in history. It would take more than a decade of painstaking work before they had a TB vaccine ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Jef Akst

    Jef Akst was managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.

Published In

April 2021

Advancing Against Metastasis

Cancer cells can spread early and lie dormant for years

Share
A greyscale image of cells dividing.
March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue
iStock: Ifongdesign

The Advent of Automated and AI-Driven Benchwork

sampled
Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Integra Logo
3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

Thermo Fisher Logo
A photo of sample storage boxes in an ultra-low temperature freezer.

Navigating Cold Storage Solutions

PHCbi logo 

Products

Sapio Sciences

Sapio Sciences Makes AI-Native Drug Discovery Seamless with NVIDIA BioNeMo

DeNovix Logo

New DeNovix Helium Nano Volume Spectrophotometer

Olink Logo

Olink® Reveal: Accessible NGS-based proteomics for every lab

Olink logo
Zymo Logo

Zymo Research Launches the Quick-16S™ Full-Length Library Prep Kit