Bile and Potatoes, 1921

One hundred years after its invention, BCG has stood the test of time as a vaccine against tuberculosis.

Written byJef Akst
| 3 min read

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ABOVE: Although the Bacille Calmette-Guérin (BCG) vaccine has never been routinely administered in the United States due to the country’s low incidence of tuberculosis, it is sometimes given to children who are regularly exposed to others with the disease. It was originally administered in an oral formulation, but researchers subsequently developed a version given as a shallow injection into the skin, shown here being administered by Reuben Erickson, the chief of the Division of Tuberculosis at Albany Hospital, in 1949.
CORNELL CAPA/THE LIFE PICTURE COLLECTION VIA GETTY IMAGES

In the early 20th century, French bacteriologists Albert Calmette and Camille Guérin at the Pasteur Institute in Lille set out to develop a vaccine to protect against tuberculosis, a potentially severe lung infection that has been responsible for more human deaths than any other pathogen in history. It would take more than a decade of painstaking work before they had a TB vaccine ...

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  • Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.

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