Book excerpt from Pox: An American History

In Chapter 5, "The Stable and the Laboratory," author Michael Willrich explores the burgeoning vaccine manufacture industry that ramped up to combat smallpox epidemics in turn-of-the-twentieth-century American cities.

Written byMichael Willrich
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PENGUIN PRESS, MARCH 2011

By the fall of 1901, the wave of American epidemics had carried smallpox to every state and territory in the union. The new mild type smallpox was the culprit in the majority of places, but deadly variola major struck several major American cities, particularly in the Northeast. Compulsory vaccination was the order of the day, enforced at the nation’s borders, in cities and towns, at workplaces, and, above all, in the public schools. The public policy was a boon to the vaccine industry, driving up demand for smallpox vaccine. American vaccine makers of the day ranged in size from rising national pharmaceutical firms such as Detroit’s Parke, Davis & Company and Philadelphia’s H. K. Mulford Company (a U.S. forerunner of today’s Merck) to the dozens ...

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