Communication helps target tumors

Proteins and nanoparticles that talk in order to more efficiently locate and treat tumors could reduce collateral damage to healthy tissues.

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Mouse tumor imaging using targeted particlesBY KUEBI VIA WIKIMEDIA COMMONS

A new technique that uses nanoparticles and engineered proteins to broadcast the location of cancer in the body can deliver up to a 40-fold greater concentration of chemotherapy drugs to tumors than untargeted cancer treatments. The new technique, published online yesterday (June 19) in Nature Materials, could inform the development of more efficient therapies that lower required doses and minimize damage to healthy tissues.

“It’s elegant work,” said Mansoor Amiji, co-director of the Nanomedicine Education and Research Consortium at Northeastern University, who was not involved in the research. The system described could eventually open doors to new therapeutic designs for a variety of cancers, he added. “This applies to many different types of systems. It has versatility.”

A big hurdle in improving cancer treatments is ...

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