Decoy Cells Trick SARS-CoV-2, Reduce Cytokines In Vitro

Genetically engineered cells that overproduce ACE2, the receptor the novel coronavirus uses to enter cells, neutralize infection in vitro and mop up inflammatory cytokines in mice.

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ABOVE: This illustration shows SARS-CoV-2 (right) binding to a genetically engineered vesicle (left) that has many ACE2 receptors, which the virus uses to gain entry into human cells.
LANG RAO & XIAOYUAN CHEN, NATIONAL INSTITUTES OF HEALTH

Scientists have summoned every trick in the book to develop a COVID-19 treatment over the last few months, from stem cells and synthetic antibodies to common over-the-counter medications and tried-and-true steroids. Some have even attempted to lure SARS-CoV-2 away from human cells by using molecular decoys. But few have tried to distract the novel coronavirus with fake human cells. Scientists reported in PNAS last week (October 6) that genetically engineered cells can bind and neutralize the coronavirus in vitro. They envision that such cellular decoys could be deployed to combat infections.

“It’s a very elegant study,” says Karolinska Institute molecular toxicologist Bengt Fadeel, who was not involved in this study. “Provided that you know ...

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Meet the Author

  • Max Kozlov

    Max is a science journalist from Boston. Though he studied cognitive neuroscience, he now prefers to write about brains rather than research them. Prior to writing for The Scientist as an editorial intern in late 2020 and early 2021, Max worked at the Museum of Science in Boston, where his favorite part of the job was dressing in a giant bee costume and teaching children about honeybees. He was also a AAAS Mass Media Fellow, where he worked as a science reporter for the St. Louis Post-Dispatch. Read more of his work at www.maxkozlov.com.

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