Diabetes Linked to Malnutrition Is Metabolically Unique: Study

Results from a small sample of Indian males suggest that lean individuals with a history of malnutrition suffer from a distinct type of diabetes characterized by a defect in insulin secretion.

Written byAlejandra Manjarrez, PhD
| 5 min read
Micrograph of a beta cell, where insulin granules are shown as blue small balls, mitochondria are colored green, and a fraction of the cell nucleus appears in purple.
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Between the 1950s and 1980s, various studies reported the prevalence of diabetes with distinctive features in young people with a history of nutritional deficiency in low- and middle-income countries. The reports motivated the World Health Organization (WHO) to create the category “malnutrition-related diabetes mellitus.” But in 1999, the same agency removed it as an official category, based on what it said was a lack of evidence “that diabetes can be caused by malnutrition or protein deficiency per se.”

A clinical study published May 27 in Diabetes Care now argues that malnutrition-related diabetes mellitus is indeed a distinct type of diabetes, and that studying it as such may improve how it is treated. By studying a small sample of diabetic and healthy males from South India, the authors concluded that diabetic patients with a body mass index (BMI) of 19 kg/m2 or below with a history of malnutrition have a defect ...

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Meet the Author

  • alejandra manjarrez

    Alejandra Manjarrez is a freelance science journalist who contributes to The Scientist. She has a PhD in systems biology from ETH Zurich and a master’s in molecular biology from Utrecht University. After years studying bacteria in a lab, she now spends most of her days reading, writing, and hunting science stories, either while traveling or visiting random libraries around the world. Her work has also appeared in Hakai, The Atlantic, and Lab Times.

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