How Do Infant Immune Systems Learn to Tolerate Gut Bacteria?

Scientists are beginning to unravel the ways in which we develop a healthy relationship with the bugs in our bodies.

Written byDiana Kwon
| 7 min read

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ISTOCK, PRETTY VECTORS

Our relationship with microbes begins early in life. As an infant passes from the womb to the world through her mother’s birth canal, she is exposed to a multitude of bacteria and fungi. Although a handful of studies now suggest that the womb may not be sterile as many once believed, microbes are much more abundant in the outside world.

How our bodies learn to peacefully coexist with cells that are not our own is still unclear. Afterall, we spend most of our lives fighting off microbial invaders. “Once you’re born, you’re assaulted by billions of bacteria, so if the babies’ [immune systems] responded in the appropriate adult manner, they would just be auto-inflammatory bundles,” says Grace Aldrovandi, a professor of pediatrics at the University ...

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Meet the Author

  • Diana is a freelance science journalist who covers the life sciences, health, and academic life. She’s a regular contributor to The Scientist and her work has appeared in several other publications, including Scientific American, Knowable, and Quanta. Diana was a former intern at The Scientist and she holds a master’s degree in neuroscience from McGill University. She’s currently based in Berlin, Germany.

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