Researchers use a new way to deliver CRISPR/Cas9 to tumors in mice, wiping out the cancer.
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Special stealth liposomes with a polyethylene glycol (PEG) coating that serves to hide the liposomes from the immune system are injected into mice with tumors (1). There, the PEG covering spontaneously falls off (2), allowing the liposomes to merge with cells and deliver CRISPR-Cas9 gene editing machinery (3). The system is designed to slice the powerful oncogene E7 (4), triggering apoptosis (5) and wiping out the tumors.
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After earning a bachelor’s degree in biology and neuroscience from Williams College, Rachael spent two years studying the tiny C. elegans worm as a lab tech at Massachusetts General Hospital/Harvard University. She then returned to school to get a master’s degree in environmental studies from Brown University, and subsequently worked as an intern at Scientific American, Discover magazine, and the Annals of Improbable Research, the originators of the yearly Ig Nobel prizes. She now freelances for both scientific and lay publications, and loves telling the stories behind the science. Find her at rachaelgorman.com or on Instagram @
When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.
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