Cancer cells can evolve ways to evade a drug’s attack, or they may already be resistant prior to treatment.
© NIRJA DESAI
Resistance to chemotherapy likely encompasses a broad range of mechanisms having to do with DNA repair, cell cycle arrest, apoptotic pathways, and others, many of which are still unknown. When it comes to molecular-targeted agents and immunotherapies, however, research has nailed down some basic strategies.
© NIRJA DESAI
Mutations within the target protein can prevent drug binding, or keep the protein active despite drug binding.
© NIRJA DESAI
