Kids’ Severe COVID-19 Reaction Bears Unique Immune Signature

The rare complication known as multisystem inflammatory syndrome in children (MIS-C) differs from both Kawasaki disease and severe adult cases of COVID-19, a study finds.

Written byShawna Williams
| 4 min read
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For months now during the COVID-19 pandemic, doctors have observed a rare but consistent scenario in a small number of kids: It starts with a SARS-CoV-2 infection, which can be mild, even asymptomatic. But weeks after the children seem to have fully recovered, they suddenly come down with symptoms that may include fever, vomiting, diarrhea, and severe abdominal pain.

“They had the infection, they got through it. And then all of a sudden . . . they can have this collapse in their bodies a few weeks later,” says Alvaro Moreira, a neonatologist at the University of Texas Health San Antonio who recently coauthored a review on the condition, known as multisystem inflammatory syndrome in children (MIS-C).

MIS-C is rare, and not all children who become severely ill or die from COVID-19 develop it. According to the Centers for Disease Control and Prevention (CDC), fewer than ...

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Meet the Author

  • Shawna was an editor at The Scientist from 2017 through 2022. She holds a bachelor’s degree in biochemistry from Colorado College and a graduate certificate in science communication from the University of California, Santa Cruz. Previously, she worked as a freelance editor and writer, and in the communications offices of several academic research institutions. As news director, Shawna assigned and edited news, opinion, and in-depth feature articles for the website on all aspects of the life sciences. She is based in central Washington State, and is a member of the Northwest Science Writers Association and the National Association of Science Writers.

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