Cover Story

Viral Virtuosos
Viral Virtuosos
Christopher S. Sullivan | Feb 1, 2015
New understanding of noncoding RNAs may solve a long-standing puzzle about how viruses orchestrate lifelong infections.
 

Features

The Energy of Life
The Energy of Life
Jeffrey Marlow and Jan Amend | Feb 1, 2015
Extremophiles should not be viewed through an anthropocentric lens; what’s extreme for us may be a perfectly comfortable environment for a microbe.
Thanks for the Memories
Thanks for the Memories
Ruth Williams | Feb 1, 2015
B and T cells may be the memory masters of the immune system, but research reveals that other cells can be primed by pathogens, too.

Contributors

Contributors

Contributors

Contributors

Meet some of the people featured in the February 2015 issue of The Scientist.

Editorial

Stubbornly Persistent

Stubbornly Persistent

Stubbornly Persistent

Microorganisms continually challenge our assumptions of what life can achieve.

Speaking of Science

Speaking of Science

Speaking of Science

Speaking of Science

February 2015's selection of notable quotes

Notebook

Mollusk Mockup

Mollusk Mockup

Mollusk Mockup

Researchers develop a “micro-scallop” meant to glide through biological fluids by opening and closing a pair of silicone shells.
Missing Mouse Mojo

Missing Mouse Mojo

Missing Mouse Mojo

Cracking the case of laboratory mice that suddenly stopped reproducing involved a little chemical sleuthing
Centennial <em>Shigella</em>

Centennial Shigella

Centennial Shigella

A strain of the dysentery-causing bacterium isolated in 1915 tells the story of a young soldier who died of the disease in the early days of World War I.
Seeing Red

Seeing Red

Seeing Red

Scientists attempt to work out how humans are able to see in the infrared.

Critic at Large

Overspending on Overhead

Overspending on Overhead

Overspending on Overhead

Federal research dollars are needlessly wasted as scientists spend more and more of their time trying to recoup operational costs.
Facing Down Emerging Viruses

Facing Down Emerging Viruses

Facing Down Emerging Viruses

A better knowledge of the pathogenesis of emerging zoonotic diseases is crucial if we want to prepare for “the next Ebola.”

Modus Operandi

Time-Lapse on the Cheap

Time-Lapse on the Cheap

Time-Lapse on the Cheap

A PhD student jury-rigs a microscopy system for high-throughput cell motility assays.

The Literature

B Cell Bosses

B Cell Bosses

B Cell Bosses

Gut bacteria in mice spur regulatory B cells to differentiate and release an anti-inflammatory cytokine.
Nibbled? No Problem

Nibbled? No Problem

Nibbled? No Problem

Making extra copies of their genomes allows some plants to better withstand damage.
Bouncing Back

Bouncing Back

Bouncing Back

In mice, a transcriptional regulator, β-catenin, activates a microRNA-processing pathway in the nucleus accumbens to promote resilience to social stress.

Profile

Engineer of Change

Engineer of Change

Engineer of Change

A chemical engineer walks into a biology lab . . . and revolutionizes bioengineering. How Robert Langer blazed a trail in drug delivery and regenerative medicine.

Scientist to Watch

Mauro Costa-Mattioli: Memory’s Puppeteer

Mauro Costa-Mattioli: Memory’s Puppeteer

Mauro Costa-Mattioli: Memory’s Puppeteer

Associate Professor, Department of Neuroscience, Baylor College of Medicine. Age: 39

Lab Tools

Pushing the Limits

Pushing the Limits

Pushing the Limits

A guide to the newest techniques for examining epigenetics in single cells
Screening Goes In Silico

Screening Goes In Silico

Screening Goes In Silico

Computational tools take some of the cost—and guesswork—out of drug discovery.

Bio Business

Lazarus Drugs

Lazarus Drugs

Lazarus Drugs

While some drugs sail through development, others suffer setbacks, including FDA rejections, before reaching the market.
 

Reading Frames

It’s Over, Man

It’s Over, Man

It’s Over, Man

The era of human male domination is ending. Will modern culture welcome the dawn of a new gender equality?

Capsule Reviews

Capsule Reviews

Capsule Reviews

Capsule Reviews

Touch, The Altruistic Brain, Is Shame Necessary?, and Future Arctic

Foundations

Scientific Publishing, 1665

Scientific Publishing, 1665

Scientific Publishing, 1665

Henry Oldenburg founded Philosophical Transactions to share scholarly news from the “Ingenious in many considerable parts of the World.”