Cover Story

Viral Virtuosos
Viral Virtuosos
Christopher S. Sullivan | Feb 1, 2015
New understanding of noncoding RNAs may solve a long-standing puzzle about how viruses orchestrate lifelong infections.
 

Features

The Energy of Life
The Energy of Life
Jeffrey Marlow and Jan Amend | Feb 1, 2015
Extremophiles should not be viewed through an anthropocentric lens; what’s extreme for us may be a perfectly comfortable environment for a microbe.
Thanks for the Memories
Thanks for the Memories
Ruth Williams | Feb 1, 2015
B and T cells may be the memory masters of the immune system, but research reveals that other cells can be primed by pathogens, too.

Contributors

Contributors
Contributors
Contributors
Meet some of the people featured in the February 2015 issue of The Scientist.

Editorial

Stubbornly Persistent
Stubbornly Persistent
Stubbornly Persistent
Microorganisms continually challenge our assumptions of what life can achieve.

Speaking of Science

Speaking of Science
Speaking of Science
Speaking of Science
February 2015's selection of notable quotes

Notebook

Mollusk Mockup
Mollusk Mockup
Mollusk Mockup
Researchers develop a “micro-scallop” meant to glide through biological fluids by opening and closing a pair of silicone shells.
Missing Mouse Mojo
Missing Mouse Mojo
Missing Mouse Mojo
Cracking the case of laboratory mice that suddenly stopped reproducing involved a little chemical sleuthing
Centennial <em>Shigella</em>
Centennial Shigella
Centennial Shigella
A strain of the dysentery-causing bacterium isolated in 1915 tells the story of a young soldier who died of the disease in the early days of World War I.
Seeing Red
Seeing Red
Seeing Red
Scientists attempt to work out how humans are able to see in the infrared.

Critic at Large

Overspending on Overhead
Overspending on Overhead
Overspending on Overhead
Federal research dollars are needlessly wasted as scientists spend more and more of their time trying to recoup operational costs.
Facing Down Emerging Viruses
Facing Down Emerging Viruses
Facing Down Emerging Viruses
A better knowledge of the pathogenesis of emerging zoonotic diseases is crucial if we want to prepare for “the next Ebola.”

Modus Operandi

Time-Lapse on the Cheap
Time-Lapse on the Cheap
Time-Lapse on the Cheap
A PhD student jury-rigs a microscopy system for high-throughput cell motility assays.

The Literature

B Cell Bosses
B Cell Bosses
B Cell Bosses
Gut bacteria in mice spur regulatory B cells to differentiate and release an anti-inflammatory cytokine.
Bouncing Back
Bouncing Back
Bouncing Back
In mice, a transcriptional regulator, β-catenin, activates a microRNA-processing pathway in the nucleus accumbens to promote resilience to social stress.
Nibbled? No Problem
Nibbled? No Problem
Nibbled? No Problem
Making extra copies of their genomes allows some plants to better withstand damage.

Profile

Engineer of Change
Engineer of Change
Engineer of Change
A chemical engineer walks into a biology lab . . . and revolutionizes bioengineering. How Robert Langer blazed a trail in drug delivery and regenerative medicine.

Scientist to Watch

Mauro Costa-Mattioli: Memory’s Puppeteer
Mauro Costa-Mattioli: Memory’s Puppeteer
Mauro Costa-Mattioli: Memory’s Puppeteer
Associate Professor, Department of Neuroscience, Baylor College of Medicine. Age: 39

Lab Tools

Pushing the Limits
Pushing the Limits
Pushing the Limits
A guide to the newest techniques for examining epigenetics in single cells
Screening Goes In Silico
Screening Goes In Silico
Screening Goes In Silico
Computational tools take some of the cost—and guesswork—out of drug discovery.

Bio Business

Lazarus Drugs
Lazarus Drugs
Lazarus Drugs
While some drugs sail through development, others suffer setbacks, including FDA rejections, before reaching the market.
 

Reading Frames

It’s Over, Man
It’s Over, Man
It’s Over, Man
The era of human male domination is ending. Will modern culture welcome the dawn of a new gender equality?

Capsule Reviews

Capsule Reviews
Capsule Reviews
Capsule Reviews
Touch, The Altruistic Brain, Is Shame Necessary?, and Future Arctic

Foundations

Scientific Publishing, 1665
Scientific Publishing, 1665
Scientific Publishing, 1665
Henry Oldenburg founded Philosophical Transactions to share scholarly news from the “Ingenious in many considerable parts of the World.”