Neurotransmitter-Regulated Immunity

Nerve signals control T cell responses, helping to explain inflammation and stroke.

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Green labelled lymphocyte cells are capable of producing acetylcholinePICTURE BY MAURICIO ROSAS-BALLINA, COURTESY OF KEVIN TRACEY

Neurotransmitters may play a bigger role in immunity than scientists had realized. In two papers published today (September 15) in Science Express, immunologists identify neurotransmitters as key players in two previously mystery-shrouded defense mechanisms: how the nervous system body puts the brakes on an overenthusiastic inflammatory response, and the reasons behind post-stroke infections.

“These connections between the brain and immune system in both health and disease are very intriguing,” said Lawrence Steinman, a professor of neurology at Stanford School of Medicine who was not involved in the study. The findings could have implications for the treatment of inflammatory disorders and stroke patients, he added.

The immune system is designed to protect the body from infection and injury, but an overactive immune response can damage organs ...

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