Public Solves Protein Structure

Players of an online game that allows users to adjust how proteins are folded have solved a decade-long protein structure mystery.

Written byJef Akst

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CENTER FOR GAME SCIENCE, DEPARTMENT OF COMPUTER SCIENCE AND ENGINEERING, UNIV. OF WASHINGTON

A small group of diverse individuals living on at least three continents, who call themselves The Contenders, have solved the structure of a protein that has stumped scientists for more than 10 years. And they did so from the comfort of their own homes, playing on online protein folding game called Foldit.

The Contenders’ solution and its validation were published today (September 18) in Nature Structural and Molecular Biology.

“This is the real deal,” said biophysicist Rhiju Das of Stanford University, who was not involved in the work. “I think this paper really shows how this is a new way of doing science that is more powerful than what a handful of experts could do.”

The protein in question was a retroviral protease of the ...

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Meet the Author

Jef Akst
Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.
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