Q&A: A Molecular Toolkit to Build SARS-CoV-2 Research Capacity

Sam Wilson discusses a user-friendly set of resources that he and his collaborators developed to aid labs pivoting to study COVID-19.

Written byAsher Jones
| 6 min read
COVID-19, SARS-CoV-2, pandemic, research, reverse genetics, toolkit, antibodies, RNA

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ABOVE: Two of the study's authors, Sam Wilson and Suzanah Rihn
STUART CAMPBELL, PHOTOGRAPHIC UNIT, UNIVERSITY OF GLASGOW

When the COVID-19 pandemic hit in early 2020, Sam Wilson and his colleagues quickly realized that they lacked the fundamental tools to study the disease-causing virus, SARS-CoV-2. “That’s when we started to produce these research tools,” including antibodies and a system for modifying the virus, says Wilson, a molecular virologist at the MRC University of Glasgow Centre for Virus Research. At the same time, Wilson noticed many non-coronavirus labs were pivoting their research to focus on COVID-19. “We were producing reagents for ourselves, so it seemed sensible to produce them for the wider research community as well,” he says.

In a paper published February 25 in PLOS Biology, Wilson and his collaborators describe a molecular toolkit for SARS-CoV-2 research, including viral isolates, a reverse genetics system for genetically manipulating the virus, and a ...

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