Q&A: A Molecular Toolkit to Build SARS-CoV-2 Research Capacity

Sam Wilson discusses a user-friendly set of resources that he and his collaborators developed to aid labs pivoting to study COVID-19.

Written byAsher Jones
| 6 min read
COVID-19, SARS-CoV-2, pandemic, research, reverse genetics, toolkit, antibodies, RNA

Register for free to listen to this article
Listen with Speechify
0:00
6:00
Share

ABOVE: Two of the study's authors, Sam Wilson and Suzanah Rihn
STUART CAMPBELL, PHOTOGRAPHIC UNIT, UNIVERSITY OF GLASGOW

When the COVID-19 pandemic hit in early 2020, Sam Wilson and his colleagues quickly realized that they lacked the fundamental tools to study the disease-causing virus, SARS-CoV-2. “That’s when we started to produce these research tools,” including antibodies and a system for modifying the virus, says Wilson, a molecular virologist at the MRC University of Glasgow Centre for Virus Research. At the same time, Wilson noticed many non-coronavirus labs were pivoting their research to focus on COVID-19. “We were producing reagents for ourselves, so it seemed sensible to produce them for the wider research community as well,” he says.

In a paper published February 25 in PLOS Biology, Wilson and his collaborators describe a molecular toolkit for SARS-CoV-2 research, including viral isolates, a reverse genetics system for genetically manipulating the virus, and a ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH