Sleep Is Critical for the Zebrafish Brain to Repair DNA Damage

Neurons can only efficiently fix genetic injuries when the animals are asleep.

Written byCatherine Offord

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One of the functions of sleep may be to repair DNA damage that has built up in the brain during waking hours, according to a study published yesterday (March 5) in Nature Communications. By using time-lapse imaging to observe the brains of zebrafish, researchers in Israel found that chromosome dynamics associated with DNA repair increased in neurons during sleep, and that sleep deprivation prevented this repair from happening efficiently.

Study coauthor Lior Appelbaum of Bar-Ilan University notes in a statement that sleep is found across the animal kingdom and that this repair role might be one of the reasons “sleep has evolved and is so conserved.”

To study what is going on in individual neurons during sleep, Appelbaum and colleagues genetically engineered zebrafish larvae to have fluorescent chromosomes in their neurons. They then used a high-resolution microscope to monitor the movements of those chromosomes when the ...

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Meet the Author

Catherine Offord
After undergraduate research with spiders at the University of Oxford and graduate research with ants at Princeton University, Catherine left arthropods and academia to become a science journalist. She has worked in various guises at The Scientist since 2016. As Senior Editor, she wrote articles for the online and print publications, and edited the magazine’s Notebook, Careers, and Bio Business sections. She reports on subjects ranging from cellular and molecular biology to research misconduct and science policy. Find more of her work at her website.
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