Study that Impregnated Male Rats Stirs Controversy

A combination of approaches, including uterus transplantation and the joining of two animals’ circulatory systems, allowed males to bear pups, according to a preprint. But some experts say the experiments were not justified.

| 7 min read
Illustration of two rats, one male and one female, that are surgically joined. The male has a uterus transplanted in, and both have embryos transplanted into their uteruses.

Register for free to listen to this article
Listen with Speechify
0:00
7:00
Share

When researchers castrated a male rat, implanted a uterus into the animal, surgically joined its circulation to that of a female rat, and transferred embryos into the uteruses of each animal, they found that the male could in fact carry a pregnancy. In 4 percent of cases, pups that were carried by male rats and delivered through Cesarean section survived.

The authors of the study, posted as a preprint on bioRxiv on June 10, say that this model could serve as a useful way to study reproductive biology, including identifying key factors in blood that could help maintain pregnancy. But some researchers question the utility of experiments using these highly artificial conditions, and the authors got so much pushback from the scientific community and the general public that they at one point requested the study’s retraction from the preprint server. For now, the preprint remains available.

“While the surgical manipulations ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Andy Tay

    Andy received his PhD from the University of California, Los Angeles, in 2014, focusing on neuromodulation and engineering. He subsequently completed his postdoctoral training at Stanford University, where he developed nanotechnologies for immuno-engineering. Andy is listed as a 2019 Forbes 30 Under 30 (North America, Science) and is a freelance writer based in Singapore.

Share
Image of a woman in a microbiology lab whose hair is caught on fire from a Bunsen burner.
April 1, 2025, Issue 1

Bunsen Burners and Bad Hair Days

Lab safety rules dictate that one must tie back long hair. Rosemarie Hansen learned the hard way when an open flame turned her locks into a lesson.

View this Issue
Conceptual image of biochemical laboratory sample preparation showing glassware and chemical formulas in the foreground and a scientist holding a pipette in the background.

Taking the Guesswork Out of Quality Control Standards

sartorius logo
An illustration of PFAS bubbles in front of a blue sky with clouds.

PFAS: The Forever Chemicals

sartorius logo
Unlocking the Unattainable in Gene Construction

Unlocking the Unattainable in Gene Construction

dna-script-primarylogo-digital
Concept illustration of acoustic waves and ripples.

Comparing Analytical Solutions for High-Throughput Drug Discovery

sciex

Products

Atelerix

Atelerix signs exclusive agreement with MineBio to establish distribution channel for non-cryogenic cell preservation solutions in China

Green Cooling

Thermo Scientific™ Centrifuges with GreenCool Technology

Thermo Fisher Logo
Singleron Avatar

Singleron Biotechnologies and Hamilton Bonaduz AG Announce the Launch of Tensor to Advance Single Cell Sequencing Automation

Zymo Research Logo

Zymo Research Launches Research Grant to Empower Mapping the RNome