Study that Impregnated Male Rats Stirs Controversy

A combination of approaches, including uterus transplantation and the joining of two animals’ circulatory systems, allowed males to bear pups, according to a preprint. But some experts say the experiments were not justified.

Written byAndy Tay
| 7 min read
Illustration of two rats, one male and one female, that are surgically joined. The male has a uterus transplanted in, and both have embryos transplanted into their uteruses.

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When researchers castrated a male rat, implanted a uterus into the animal, surgically joined its circulation to that of a female rat, and transferred embryos into the uteruses of each animal, they found that the male could in fact carry a pregnancy. In 4 percent of cases, pups that were carried by male rats and delivered through Cesarean section survived.

The authors of the study, posted as a preprint on bioRxiv on June 10, say that this model could serve as a useful way to study reproductive biology, including identifying key factors in blood that could help maintain pregnancy. But some researchers question the utility of experiments using these highly artificial conditions, and the authors got so much pushback from the scientific community and the general public that they at one point requested the study’s retraction from the preprint server. For now, the preprint remains available.

“While the surgical manipulations ...

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  • Andy received his PhD from the University of California, Los Angeles, in 2014, focusing on neuromodulation and engineering. He subsequently completed his postdoctoral training at Stanford University, where he developed nanotechnologies for immuno-engineering. Andy is listed as a 2019 Forbes 30 Under 30 (North America, Science) and is a freelance writer based in Singapore.

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