chemical visualization of a G-quadruplex
Strange DNA Structures Linked to Cancer
A study reveals a connection between the loss of enzymes responsible for removing methyl groups from DNA, nucleic acid knots, and cancer development in mice.
ABOVE: WIKIMEDIA COMMONS, Thomas Splettstoesser
Strange DNA Structures Linked to Cancer
Strange DNA Structures Linked to Cancer

A study reveals a connection between the loss of enzymes responsible for removing methyl groups from DNA, nucleic acid knots, and cancer development in mice.

A study reveals a connection between the loss of enzymes responsible for removing methyl groups from DNA, nucleic acid knots, and cancer development in mice.

ABOVE: WIKIMEDIA COMMONS, Thomas Splettstoesser
knockout mice
Two Studies Question Function of Bone Hormone Osteocalcin
Ruth Williams | May 29, 2020
Independently produced knockout mouse strains fail to find evidence of the bone protein’s endocrine functions, and divide researchers’ opinions.
Study Challenges CRISPR Method for Making Conditional Knockout Mice
Sukanya Charuchandra | Sep 28, 2018
Researchers from 17 labs report low efficacy rates for the popular technique.
Image of the Day: Morphing Cells
The Scientist Staff, The Scientist Staff | Mar 27, 2018
By removing a single gene, researchers change the developmental fate of tumor cells in mice.  
Oliver Smithies, Technologist Behind Knockout Mice, Dies
Bob Grant | Jan 12, 2017
The Nobel laureate and Lasker awardee developed tools that facilitated decades of genetics research, including starch gel electrophoresis and gene targeting.
Immune Defect Detected in Knockout Mice
Tanya Lewis | May 20, 2016
Researchers have identified a mutation in a commonly used commercial mouse strain that could impact experimental results.
Inhibiting Sperm Protein Causes Infertility
Karen Zusi | Oct 5, 2015
Two drugs targeting a protein in sperm cause reversible infertility in male mice, providing new hope for a male contraceptive.
Passenger Mutations Can Skew Results
Kate Yandell | Jul 7, 2015
Some genetically engineered mice harbor unwanted mutations that hitchhike alongside desired modifications, affecting experimental outcomes.
Binge-Drinking Trigger?
Jef Akst | May 12, 2015
Researchers identify a protein linked to excessive consumption of alcohol in animal models.
CRISPR Knock-in Mouse Debuts
Bob Grant | Sep 29, 2014
Researchers have created a line of model mice that naturally express Cas9, paving the way for rapid precision gene-editing.
Another Obesity-Associated Gene
Rina Shaikh-Lesko | Mar 13, 2014
Researchers find a new gene connected to obesity in a surprising part of the genome.
First, Do No Harm…
Jim Woodgett | Jun 9, 2011
Is DNA damage an inevitable consequence of epigenetic reprogramming?