knockout mice
Image of the Day: Morphing Cells
Image of the Day: Morphing Cells
The Scientist Staff | Mar 27, 2018
By removing a single gene, researchers change the developmental fate of tumor cells in mice.  
Oliver Smithies, Technologist Behind Knockout Mice, Dies
Oliver Smithies, Technologist Behind Knockout Mice, Dies
Bob Grant | Jan 12, 2017
The Nobel laureate and Lasker awardee developed tools that facilitated decades of genetics research, including starch gel electrophoresis and gene targeting.
Immune Defect Detected in Knockout Mice
Immune Defect Detected in Knockout Mice
Tanya Lewis | May 20, 2016
Researchers have identified a mutation in a commonly used commercial mouse strain that could impact experimental results.
Inhibiting Sperm Protein Causes Infertility
Inhibiting Sperm Protein Causes Infertility
Karen Zusi | Oct 5, 2015
Two drugs targeting a protein in sperm cause reversible infertility in male mice, providing new hope for a male contraceptive.
Passenger Mutations Can Skew Results
Passenger Mutations Can Skew Results
Kate Yandell | Jul 7, 2015
Some genetically engineered mice harbor unwanted mutations that hitchhike alongside desired modifications, affecting experimental outcomes.
Binge-Drinking Trigger?
Binge-Drinking Trigger?
Jef Akst | May 12, 2015
Researchers identify a protein linked to excessive consumption of alcohol in animal models.
CRISPR Knock-in Mouse Debuts
CRISPR Knock-in Mouse Debuts
Bob Grant | Sep 29, 2014
Researchers have created a line of model mice that naturally express Cas9, paving the way for rapid precision gene-editing.
Another Obesity-Associated Gene
Another Obesity-Associated Gene
Rina Shaikh-Lesko | Mar 13, 2014
Researchers find a new gene connected to obesity in a surprising part of the genome.
First, Do No Harmā€¦
Jim Woodgett | Jun 9, 2011
Is DNA damage an inevitable consequence of epigenetic reprogramming?