Conceptual image of blue neurons with glowing segments over blue background.
CRACK Method Reveals Novel Neuron Type in Mouse Brain
A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.
ABOVE: © istock.com, ismagilov
CRACK Method Reveals Novel Neuron Type in Mouse Brain
CRACK Method Reveals Novel Neuron Type in Mouse Brain

A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.

A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.

ABOVE: © istock.com, ismagilov

microscopy

Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist Staff | Dec 1, 2021
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
computerized image of different layers of a cell shown at great detail
New Studies Enable a Clearer View Inside Cells
Andrew Chapman | Nov 4, 2021
Armed with improved imaging techniques and supercomputers, researchers are generating detailed three-dimensional images of cellular structures that anyone can explore.
New insights reveal how herpesvirus infiltrates the nervous system.
Herpes Kidnaps Proteins to Take Up Residence in the Nervous System
Roni Dengler, PhD | Dec 6, 2021
The herpes virus hitches a ride to the nuclei of neurons from a surprising source.
Izzy Jayasinghe stands in front of a projection of a map, looking as though she is speaking
Izzy Jayasinghe Harnesses Cutting-Edge Microscopy to Image Cells
Shawna Williams | Jul 1, 2021
The University of Sheffield researcher devises new protocols to gain molecular-level insights.
Magnified image featuring a full view of a bdelloid rotifer recovered from permafrost (labeled A) along with two insets: one side view of the organism’s head (labeled B) and a view of its mouthparts (labeled C)
Rotifers Bounce Back After Being Frozen for 24,000 Years
Lisa Winter | Jun 8, 2021
The hardy animals were pulled from the permafrost in Siberia, giving scientists the opportunity to study how they survive extreme conditions.
Finding CAR T Cells in Solid Tumors by Single-Cell Resolution
Finding CAR T Cells in Solid Tumors at Single-Cell Resolution
The Scientist Creative Services Team in collaboration with Miltenyi Biotec | Nov 12, 2021
Rita Pfeifer will discuss visualizing and quantifying CAR T-cell infiltration into solid tumors with 3-D light sheet fluorescence microscopy (LSFM).
A scanning electron micrograph of a coculture of E. coli and Acinetobacter baylyi. Nanotubes can be seen extending from the E. coli.
What’s the Deal with Bacterial Nanotubes?
Sruthi S. Balakrishnan | Jun 1, 2021
Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?
An illustration of a flask of bacteria, a weighted microscope slide, and two bacteria exchanging materials via nanotubes.
Infographic: Sources of Variation in Bacterial Nanotube Studies
Sruthi S. Balakrishnan | Jun 1, 2021
Differences in how researchers prepare and image samples can lead to discrepancies in their results.
Discover how to scale up cellular assays during drug discovery
High-Throughput Solutions for Lead Candidate Discovery
The Scientist Creative Services Team, Thermo Fisher Scientific | Oct 18, 2021
New technologies allow researchers to scale up assays for cellular functions.
Ibrahim Cissé’s Tools Provide a Lens to Watch RNA Production
Jef Akst | Sep 1, 2020
The MIT physicist has demonstrated the importance of clusters of RNA polymerase and other transcription mediators in regulating RNA production.
Image of the Day: A Mouse Brain Slice Becomes Art
Amy Schleunes | Apr 1, 2020
A fluorescent image of murine hippocampal cells is the winning microscopy image from more than 400 submissions from 65 countries for Olympus’s 2019 Image of the Year Award.
Mapping the Brain in 3-D
Mapping the Brain in 3-D
Nathan Ni, PhD | Oct 5, 2021
3-D brain atlases help scientists better understand brain function in physiological and pathological situations.
Microscopy and Imaging Leader Shinya Inoué Dies
Jef Akst | Oct 7, 2019
The long-time Marine Biological Laboratory scientist was known for using his own hand-built microscopes to image the dynamics of live cells.
Caught on Camera
The Scientist Staff | Oct 1, 2019
Selected Images of the Day from the-scientist.com
800x560-oct-5-2021
Technique Talk: Live-Cell Imaging Strategies to Quantify Phagocytosis
The Scientist Creative Services Team in collaboration with Sartorius | Sep 8, 2021
Discover how to image and quantitate phagocytosis in real time
traced mouse neurons
Image of the Day: Brain Map
Nicoletta Lanese | Sep 6, 2019
Scientists traced 1,000 neurons through the mouse brain, uncovering new details about how the organ is wired.
RNA droplets
Image of the Day: Liquid Compartments
Nicoletta Lanese | Aug 28, 2019
Membraneless organelles appear highly sensitive to ion concentrations in their environment.
Scientific Breakthroughs with Cryogenic Electron Microscopy
The Scientist Creative Services Team, Thermo Fisher Scientific | Jun 10, 2021
Structures made via cryo-EM give researchers insights into SARS-CoV-2, HIV, neurological disorders, cancer, and more.
Richard Van Duyne
Chemist Richard Van Duyne Dies
Catherine Offord | Aug 16, 2019
The Northwestern University professor developed surface-enhanced Raman spectroscopy, an invaluable technique for detecting and identifying individual molecules.