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Illustration of myelinated neuron axons in light blue, with spindly blue and purple cells interspersed among them.
A Gene Variant Linked to Alzheimer’s May Disrupt Myelin Production
The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.
A Gene Variant Linked to Alzheimer’s May Disrupt Myelin Production
A Gene Variant Linked to Alzheimer’s May Disrupt Myelin Production

The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.

The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.

myelin
illustration of neurons in blue with synapses lighting up
Gut Molecule Linked to Decreased Myelination in Mouse Brains
Angie Voyles Askham, Spectrum | Feb 17, 2022 | 4 min read
A study shows that a molecule produced by intestinal microbes can enter the brain and that its presence is also associated with altered brain connectivity.
Inadequate Myelination of Neurons Tied to Autism: Study
Lisa Winter | Feb 4, 2020 | 2 min read
A mouse model of autism and postmortem brains of autistic individuals showed a lack of mature oligodendrocytes and less myelination than controls.
Image of the Day: Telling Scans
Aggie Mika | Oct 16, 2017 | 1 min read
In children’s brain scans, scientists uncovered signs of multiple sclerosis before the kids showed any symptoms of the disease.
Week in Review: October 13–17
Jef Akst | Oct 17, 2014 | 4 min read
Snail not extinct after all; results too good to be true?; mice need myelin production for motor learning; keeping the brain young; the evolution of archaea
Myelin’s Role in Motor Learning
Ashley P. Taylor | Oct 16, 2014 | 3 min read
The production of new myelin in the brain—a function of non-neuronal glial cells—may be necessary for motor learning, a mouse study shows.
Remodeling Myelin
Dan Cossins | Aug 1, 2013 | 2 min read
New oligodendrocytes in the adult mouse brain appear to remodel existing myelin sheaths, which may fine-tune the speed of nerve impulses.
Stem Cells Myelinate Human Brain
Sabrina Richards | Oct 10, 2012 | 4 min read
In a Phase I trial, researchers show that neural stem cells transplanted into humans can differentiate and begin producing myelin.
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