salmonella bacteria 3d illustration
Salmonella Injection Helps the Mouse Immune System Kill Tumors
Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.
Salmonella Injection Helps the Mouse Immune System Kill Tumors
Salmonella Injection Helps the Mouse Immune System Kill Tumors

Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.

Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.

Salmonella
Illustration showing how following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano- particles near tumors in mice.
Infographic: Salmonella Shuttle Tumor Antigens to Immune Cells
Dan Robitzski | May 16, 2022
Nanoparticle-coated bacteria carry cancer-derived proteins to dendritic cells, enabling the immune system to launch a response in a mouse model.
Salmonella (pink) invading a human epithelial cell (yellow)
Modified Salmonella Revs Immune Response, Combats Tumors in Mice
Natalia Mesa | Feb 3, 2022
When coated with positively charged particles, the bacteria shuttled antigens out of tumors and activated the immune system, a study finds.
Salmonella living within macrophages can survive antibiotic treatment and potentially give rise to resistance by two different mechanisms that slow or arrest their growth.
Bacteria Go Dormant to Survive Antibiotics and Restart Infections
Niki Spahich, PhD
In Salmonella, two seemingly similar antibiotic survival strategies result from very different molecular mechanisms.
Colorized scanning electron micrograph of Salmonella bacteria in intestinal tissue
Gut Infections Help Shield Intestinal Neurons from Future Damage
Annie Melchor | Nov 19, 2021
In mice, a kind of immune memory appears to protect the cells against future harm, a finding that could provide insight into treatments for irritable bowel syndrome and other inflammatory digestive conditions.
illustration of colorful microbes inside a person's stomach and intestines
How Commensal Gut Bacteria Keep Pathogens in Check
Alejandra Manjarrez | Oct 14, 2021
Recent studies describe how resident microbiota appear to outcompete unwelcome visitors, either with superior weaponry or by guzzling up local resources.  
Researchers target E. coli in the mouse gut
Modifying the Microbiome In Vivo, One Species or Gene at a Time
Niki Spahich, PhD
To manipulate the microbiome, researchers engineered a CRISPR delivery system that precisely targets bacteria in the mouse gut.
Segmented filamentous bacteria artificially colored in green attach to the intestinal wall of a mouse
Gut Microbes Help Coordinate Immune Activity in Mice
Catherine Offord | Jul 29, 2021
The microbiota helps align a mouse’s innate immune system with its feeding patterns, prepping the animal to fend off infection when it’s most likely to be eating.
A computer-generated graphic showing a cross-section of red-colored bacteria, with the locations of the protein APOL3 labeled in green.
Human Protein Dissolves Bacterial Membranes
Abby Olena | Jul 15, 2021
The protein, apolipoprotein L3, destroys invading microbes by acting as a detergent in the cytosol.
Janelle Ayres Explores the Ways in Which Animals Tolerate Disease
Amy Schleunes | Jun 1, 2020
The Salk Institute researcher was one of the first to show that killing a pathogen isn’t the only way to survive an infection.
Space-Grown Lettuce Is Safe and Astronaut-Approved
Amy Schleunes | Mar 9, 2020
NASA’s vegetable production system, known as Veggie, may help pave the way for more sophisticated systems that could supplement astronauts’ diets during long trips to space.
gut microbe defend against salmonella Mucispirillum
Image of the Day: Microbes At War
Chia-Yi Hou | Apr 23, 2019
Scientists identify microbes in mice that help defend against Salmonella.
black lab mice microbiome
Microbes May Take Some of the Blame for the Reproducibility Crisis
Emma Yasinski | Apr 5, 2019
Scientists find varied microbiota among the same strain of mice from four vendors—and that variability affects their susceptibility to infection.
Image of the Day: First Contact
Catherine Offord | Oct 11, 2018
Cryo-electron tomography reveals how Salmonella sets up physical interactions with host cells.
Inflammation Drives Gut Bacteria Evolution
Ruth Williams | Mar 16, 2017
Viruses within Salmonella rapidly spread genes throughout the bacterial population during a gut infection, scientists show.
Toward Killing Cancer with Bacteria
Ruth Williams | Feb 8, 2017
Researchers employ an engineered microbe to destroy tumor cells in mice.
Blood-Gut Barrier
Ruth Williams | Nov 12, 2015
Scientists identify a barrier in mice between the intestine and its blood supply, and suggest how Salmonella sneaks through it.
Parsing Pathogens
Jef Akst | Jun 1, 2014
Meet the peptide-covered microcantilever device capable of differentiating subtypes of Salmonella.
Immune Response Promotes Infection
Laasya Samhita | Feb 6, 2014
Salmonella enterica can exploit a standard immune response in mice to promote its own growth.
Decoding Bacterial Methylomes
Kate Yandell | May 15, 2013
A new technique could soon spur unprecedented insight into the role of bacterial epigenetics in the evolution of pathogen virulence.