tau protein

The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.

Genetic, transcriptomic, and epigenetic data reveal molecular mechanisms tying these disorders to each other and to immune disfunction.

Patients who received the drug fared better cognitively and functionally than those taking placebo, but still experienced losses in performance.

An imaging agent reveals aggregated tau protein in the brain during PET scans and could improve the diagnosis of neurodegenerative diseases, particularly tauopathies.

New studies show that elevated levels of a form of tau called p-tau217 can accurately distinguish Alzheimer’s disease from other forms of dementia, and perhaps even predict it.

A woman whose DNA suggested she’d develop early-onset dementia staved off cognitive decline for decades.

Endolysosome leakiness allows tau to build up in cells.

In brain samples from people with Alzheimer’s disease, the protein aggregates more strongly bound proteins involved in processing RNA, the same study finds.

Patients who suffer a traumatic brain injury may exhibit abnormally abundant tau protein many years later, a new in vivo imaging technique reveals.

Mutations within the MS4A gene cluster have been linked to changes in protein levels that affect disease risk.

Using super-resolution microscopy, scientists learned how mutant tau causes a memory-related protein to clump up in mouse neurons.

A study hints that it might be possible to diagnose chronic traumatic encephalopathy, a neurodegenerative disease associated with frequent head injuries, while patients are still living.

Exposing mice to an hour of 40-hertz stimuli every day for a week reduced levels of amyloid-β plaques and tau protein, and improved cognition.

An enzyme of the bacteria Porphyromonas gingivalis has been found in the brains of patients with the disorder, and causes neurodegeneration in mice.

Tau proteins disrupt the movement of molecules into and out of neuronal cells’ nuclei.

A study explores how nuclear pore complexes are disrupted in Alzheimer’s disease.

Levels of tau, amyloid-β 42, and IL-10 extracted from extracellular vesicles that started out in the brain were higher in military personal suffering head injuries compared with healthy soldiers.

A proposed definition of the disease emphasizes signs of neurodegeneration and the presence of β-amyloid and tau, rather than cognitive symptoms.

The findings suggest that faster synthesis, rather than decreased clearance, causes the protein to build up in neurons.