Eli Lilly Claims New Drug Can Slow Alzheimer’s-Related Decline
Eli Lilly Claims New Drug Can Slow Alzheimer’s-Related Decline
Patients who received the drug fared better cognitively and functionally than those taking placebo, but still experienced losses in performance.
Eli Lilly Claims New Drug Can Slow Alzheimer’s-Related Decline
Eli Lilly Claims New Drug Can Slow Alzheimer’s-Related Decline

Patients who received the drug fared better cognitively and functionally than those taking placebo, but still experienced losses in performance.

Patients who received the drug fared better cognitively and functionally than those taking placebo, but still experienced losses in performance.

tau protein
New Tracer Gives Clear Picture of Alzheimer’s and Other Dementias
New Tracer Gives Clear Picture of Alzheimer’s and Other Dementias
Ian Le Guillou | Oct 29, 2020
An imaging agent reveals aggregated tau protein in the brain during PET scans and could improve the diagnosis of neurodegenerative diseases, particularly tauopathies.
Experimental Blood Test Could Flag Alzheimer’s
Experimental Blood Test Could Flag Alzheimer’s
Kerry Grens | Jul 29, 2020
New studies show that elevated levels of a form of tau called p-tau217 can accurately distinguish Alzheimer’s disease from other forms of dementia, and perhaps even predict it.
<em>APOE</em> Mutation Linked to Protection From Alzheimer&rsquo;s: Case Study
APOE Mutation Linked to Protection From Alzheimer’s: Case Study
Catherine Offord | Nov 5, 2019
A woman whose DNA suggested she’d develop early-onset dementia staved off cognitive decline for decades.
Image of the Day: Tau Aggregation
Image of the Day: Tau Aggregation
Emily Makowski | Oct 17, 2019
Endolysosome leakiness allows tau to build up in cells.
Tau Linked to RNA Splicing Errors in Flies
Tau Linked to RNA Splicing Errors in Flies
Emily Makowski | Oct 8, 2019
In brain samples from people with Alzheimer’s disease, the protein aggregates more strongly bound proteins involved in processing RNA, the same study finds.
Tau Pathology Present Decades After a Single Brain Injury
Tau Pathology Present Decades After a Single Brain Injury
Ruth Williams | Sep 9, 2019
Patients who suffer a traumatic brain injury may exhibit abnormally abundant tau protein many years later, a new in vivo imaging technique reveals.
Image of the Day: Alzheimer&rsquo;s Genes
Image of the Day: Alzheimer’s Genes
Nicoletta Lanese | Aug 19, 2019
Mutations within the MS4A gene cluster have been linked to changes in protein levels that affect disease risk.
Image of the Day: Clustered Memories
Image of the Day: Clustered Memories
Nicoletta Lanese | Aug 5, 2019
Using super-resolution microscopy, scientists learned how mutant tau causes a memory-related protein to clump up in mouse neurons.
PET Scans Reveal Elevated Tau in NFL Players&rsquo; Brains
PET Scans Reveal Elevated Tau in NFL Players’ Brains
Jef Akst | Apr 12, 2019
A study hints that it might be possible to diagnose chronic traumatic encephalopathy, a neurodegenerative disease associated with frequent head injuries, while patients are still living.
Rapidly Flashing Lights and Sounds Reduces Alzheimer&rsquo;s in Mice
Rapidly Flashing Lights and Sounds Reduces Alzheimer’s in Mice
Jef Akst | Mar 15, 2019
Exposing mice to an hour of 40-hertz stimuli every day for a week reduced levels of amyloid-β plaques and tau protein, and improved cognition.
Gum Disease Could Drive Alzheimer&rsquo;s: Study
Gum Disease Could Drive Alzheimer’s: Study
Ashley Yeager | Jan 24, 2019
An enzyme of the bacteria Porphyromonas gingivalis has been found in the brains of patients with the disorder, and causes neurodegeneration in mice.
Faulty Cell Transport System Implicated in Alzheimer&rsquo;s Disease
Faulty Cell Transport System Implicated in Alzheimer’s Disease
Ashley Yeager | Nov 1, 2018
Tau proteins disrupt the movement of molecules into and out of neuronal cells’ nuclei.
Infographic: Leaky Gates
Infographic: Leaky Gates
Ashley Yeager | Nov 1, 2018
A study explores how nuclear pore complexes are disrupted in Alzheimer’s disease.
Exosomes in Blood Indicate Mild TBI: Study
Exosomes in Blood Indicate Mild TBI: Study
Ashley Yeager | Jul 13, 2018
Levels of tau, amyloid-β 42, and IL-10 extracted from extracellular vesicles that started out in the brain were higher in military personal suffering head injuries compared with healthy soldiers.
Alzheimer’s Should be Characterized by Biomarkers: Report
Alzheimer’s Should be Characterized by Biomarkers: Report
Diana Kwon | Apr 10, 2018
A proposed definition of the disease emphasizes signs of neurodegeneration and the presence of β-amyloid and tau, rather than cognitive symptoms.
Tau Production Increased in Alzheimer’s Patients
Tau Production Increased in Alzheimer’s Patients
Jim Daley | Mar 21, 2018
The findings suggest that faster synthesis, rather than decreased clearance, causes the protein to build up in neurons.
Image of the Day: Unseen Trauma
Image of the Day: Unseen Trauma
The Scientist Staff | Jun 20, 2017
Pressure from simulated blast waves, similar to those generated by explosives, induced molecular markers of stress and injury within mouse retinas.
Speaking of Neuroscience
Speaking of Neuroscience
Jef Akst, Mary Beth Aberlin | Nov 18, 2016
A selection of notable quotes from the annual Society for Neuroscience meeting
Toward an Immunotherapy for Alzheimer’s Disease
Toward an Immunotherapy for Alzheimer’s Disease
Tanya Lewis | Jul 28, 2016
Targeting tau antibodies does not require effector function, researchers report.