An imaging agent reveals aggregated tau protein in the brain during PET scans and could improve the diagnosis of neurodegenerative diseases, particularly tauopathies.

New studies show that elevated levels of a form of tau called p-tau217 can accurately distinguish Alzheimer’s disease from other forms of dementia, and perhaps even predict it.

A woman whose DNA suggested she’d develop early-onset dementia staved off cognitive decline for decades.

Endolysosome leakiness allows tau to build up in cells.

In brain samples from people with Alzheimer’s disease, the protein aggregates more strongly bound proteins involved in processing RNA, the same study finds.

Patients who suffer a traumatic brain injury may exhibit abnormally abundant tau protein many years later, a new in vivo imaging technique reveals.

Mutations within the MS4A gene cluster have been linked to changes in protein levels that affect disease risk.

Using super-resolution microscopy, scientists learned how mutant tau causes a memory-related protein to clump up in mouse neurons.

A study hints that it might be possible to diagnose chronic traumatic encephalopathy, a neurodegenerative disease associated with frequent head injuries, while patients are still living.