Conceptual image of gene expression in DNA
Enhancers: Conserved in Activity, Not in Sequence
Certain stretches of DNA that regulate gene expression have evolved differently from protein-coding genes.
ABOVE: © ISTOCK.COM, KTSIMAGE
Enhancers: Conserved in Activity, Not in Sequence
Enhancers: Conserved in Activity, Not in Sequence

Certain stretches of DNA that regulate gene expression have evolved differently from protein-coding genes.

Certain stretches of DNA that regulate gene expression have evolved differently from protein-coding genes.

ABOVE: © ISTOCK.COM, KTSIMAGE
transcription
Abstract illustration of DNA
Signaling Dynamics Fine-Tune Gene Expression
Ruth Williams | Sep 3, 2021
The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.
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Human Cells Can Synthesize DNA in Their Cytoplasm
Alejandra Manjarrez | Feb 8, 2021
While studying a degenerative eye disease, researchers find the first evidence that cells produce endogenous DNA in the cytoplasm. Drugs that block this activity are linked with reduced risk of atrophic age-related macular degeneration.
The Scientist Speaks - Thieves on the Inside: Viral Control of Host Gene Expression
Niki Spahich, PhD | May 25, 2021
Britt Glaunsinger discusses how viruses steal from their hosts to take over cellular processes and promote their own survival.
Ibrahim Cissé’s Tools Provide a Lens to Watch RNA Production
Jef Akst | Sep 1, 2020
The MIT physicist has demonstrated the importance of clusters of RNA polymerase and other transcription mediators in regulating RNA production.
Left-Handed DNA Has a Biological Role Within a Dynamic Genetic Code
Rachel Brazil | Jun 1, 2020
Once considered an unimportant curiosity, Z-DNA is now recognized to provide an on-the-fly mechanism to regulate how an RNA transcript is edited.
Infographic: DNA Isn’t Always Right-Handed
Rachel Brazil | Jun 1, 2020
When the nucleic acid spirals to the left, it takes on a zig-zag shape known as Z-DNA that appears to regulate RNA editing.
Moderna’s Coronavirus Vaccine Spurs Immune Response: Early Data
Ashley Yeager | May 18, 2020
A clinical trial of the shot in eight volunteers suggests that it is safe and that it generates antibodies that neutralize SARS-CoV-2, but further testing is needed, scientists say.
DNA Damage Linked to Brain Overgrowth in Autism
Abby Olena | Feb 5, 2020
Cell lines from individuals with macrocephalic autism spectrum disorder have an increased number of double-strand breaks in the DNA of long neural genes.
a pair of scissors cuts a film strip that's curled into a helix
Alternative Splicing Provides a Broad Menu of Proteins for Cells
Gabrielle M. Gentile, Hannah J. Wiedner, Emma R. Hinkle, and Jimena Giudice | Jan 13, 2020
It’s now clear that gene transcripts can be constructed in various ways, yet many questions remain about the process.
rna-seq rna sequencing bias dataset transcript
Technical Bias Widespread in RNA-Seq Datasets
Diana Kwon | Nov 21, 2019
Genes that are exceptionally long or short are overrepresented in some published reports, which can lead to misinterpreted results.
translation gene genetics ribosome enhancers knowable magazine
What Does It Look Like to “Turn On” a Gene?
Alla Katsnelson, Casey Rentz, Knowable Magazine | May 3, 2019
Only recently have scientists directly witnessed this most pivotal of events in biology, thanks to new technology that allows them to observe the process in living cells. It’s teaching them a lot.
A New Role for Yeast Introns: Helping Cells Cope Under Stress
Katarina Zimmer | Jan 16, 2019
Two studies contest the idea that the noncoding sequences are just “junk DNA,” demonstrating that they play important roles in the regulation of cell growth.
Genetic Neurologist: A Profile of Huda Zoghbi
Anna Azvolinsky | Nov 1, 2018
Turning to molecular genetics, the Baylor pediatric neurologist and geneticist works to discover the biological basis for the rare neurological diseases she sees in her patients.
A Brush with Inheritance, 1878
Catherine Offord | Feb 1, 2018
Lampbrush chromosomes, first observed in the 19th century, still offer an unparalleled glimpse into how genetic information is organized in the cell.
Paused RNA Polymerase Quashes New Initiation of Transcription
Shawna Williams | Oct 1, 2017
Pauses may help cells fine-tune gene expression.
The Role of DNA Base Modifications
Skirmantas Kriaucionis | Sep 1, 2017
Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.
Infographic: The Various Forms of Methylated DNA
Skirmantas Kriaucionis | Aug 31, 2017
To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.
The RNA Age: A Primer
Ruth Williams | May 11, 2017
Our guide to all known forms of RNA, from cis-NAT to vault RNA and everything in between.
Noncoding RNA Helps Cells Recover from DNA Damage
Diana Kwon | May 1, 2017
Scientists discover transcripts from the same gene that can express both proteins and noncoding RNA.