Tools for Drools

A general guide to collecting and processing saliva

Written byKelly Rae Chi
| 8 min read

Register for free to listen to this article
Listen with Speechify
0:00
8:00
Share

© DAVID TROOD/GETTI IMAGESHealthy adults secrete roughly 1 to 1.5 liters of saliva each day from three major pairs of glands that are in close contact with the bloodstream. Mostly water, spit also contains electrolytes and proteins, including glycoproteins that form mucus, enzymes that break down food and bacteria, and secretory antibodies.

Besides maintaining our oral health, saliva harbors clues about our ancestry and whether we might be fighting an infection, are overstressed, or have a hormonal imbalance. In the future, the watery fluid may even provide a rapid screen for a recent heart attack or distinguish between bacterial and viral infections. Indeed, characterizing the oral microbiome, the collection of all of the microorganisms in a person’s mouth, and its potential links to health and disease is its own emerging field. (See “The Body’s Ecosystem,” The Scientist, August 2014)

“In the past few years, there’s been a lot more optimism about what can be done [using] saliva,” says Paul Slowey, CEO of Oasis Diagnostics in Vancouver, Washington. That’s because technologies are now sensitive enough to detect and ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Eppendorf Logo

Research on rewiring neural circuit in fruit flies wins 2025 Eppendorf & Science Prize

Evident Logo

EVIDENT's New FLUOVIEW FV5000 Redefines the Boundaries of Confocal and Multiphoton Imaging

Evident Logo

EVIDENT Launches Sixth Annual Image of the Year Contest

10x Genomics Logo

10x Genomics Launches the Next Generation of Chromium Flex to Empower Scientists to Massively Scale Single Cell Research