Increasing experimental throughput produces powerful results. However, setting up assays that test numerous samples and replicates can be tedious. As throughput increases, using a single channel pipette for each sample and reagent transfer becomes a burden. Researchers become fatigued as they move the pipette plunger up and down hundreds of times to fill a 96- or 384-well plate, leading to inconsistent liquid transfers and unreliable results. The repetitive motions associated with pipetting can strain and damage the hand, arm, and shoulder.
Multichannel pipettes provide a solution to this problem. By transferring multiple samples at once, they increase experimental reproducibility and decrease the number of pipetting actions. However, standard multichannel pipettes still have their downsides. For example, the interior of some multichannel pipettes houses tubing connecting the internal mechanism. Over time, this tubing can become fragile and porous, leading to leaks within the pipette.
An even greater pain point comes when ...