A bright, illuminated, yellow cluster of spheres, representing a mutated base pair, stands out from a double helix of deep red base pairs joined by blue hydrogen bonds
Study: Sickle Cell Mutation Driven by Pressure, Not Random Chance
New research finds that the appearance of the HbS mutation, which protects against malaria but leads to sickle cell disease when present in two copies, was more common in sperm samples from men in Ghana, where malaria risk is high, than Europeans.
ABOVE: © ISTOCK.COM, SILVERV
Study: Sickle Cell Mutation Driven by Pressure, Not Random Chance
Study: Sickle Cell Mutation Driven by Pressure, Not Random Chance

New research finds that the appearance of the HbS mutation, which protects against malaria but leads to sickle cell disease when present in two copies, was more common in sperm samples from men in Ghana, where malaria risk is high, than Europeans.

New research finds that the appearance of the HbS mutation, which protects against malaria but leads to sickle cell disease when present in two copies, was more common in sperm samples from men in Ghana, where malaria risk is high, than Europeans.

ABOVE: © ISTOCK.COM, SILVERV

PCR

Illustration of man receiving a COVID test.
Opinion: What COVID-19 Has Taught Us About the Importance of Testing
Mark Kessel | Feb 1, 2022
The pandemic has yielded many lessons. One is that adequate and well-distributed diagnostics are key to battling disease outbreaks.
Man in black suit looking at camera
Pioneering Geneticist C. Thomas Caskey Dies at 83
Natalia Mesa | Jan 28, 2022
Caskey’s contributions to the field were instrumental to modern genetics.
Discover how to avoid PCR inhibition
Crude Samples, Optimal Results
The Scientist Creative Services Team, MilliporeSigma | Apr 19, 2022
Discover how to avoid the PCR inhibitors that lurk in most nucleic acid samples.
two women wearing plastic gloves hold up hand-sized air-capture devices in a wooded area.
Scientists ID Dozens of Plants, Animals from Free-Floating DNA
Dan Robitzski | Jan 6, 2022
In a trio of studies, researchers report capturing and analyzing airborne environmental DNA from a wide variety of plants and animals, suggesting a new way of monitoring which terrestrial species are present in an area.
The Researchers Who Pivoted to COVID-19: One Year On
Shawna Williams | Jul 1, 2021
The Scientist checks in on scientists who switched gears to combat the pandemic.
Cartoon rendering of a PCR reaction
Five Key Components for a Successful PCR
MilliporeSigma | Apr 6, 2022
Fixing a PCR might be as simple as adjusting a component or two
Special report
a hand in a blue glove holds a clear plastic multiwell plate in a laboratory with foil-wrapped plates on a metal shelf in the background
Labs Worldwide Still Struggling Amid Broken Supply Chains
Katarina Zimmer | May 21, 2021
Countries outside the US and Europe that are already used to long wait times for laboratory supplies are facing greater research disruptions than ever during the pandemic.
a person in a white lab coat with a blue glove inserting a clear pcr tube into a which thermocycler while holding an orange box
Coronavirus Mutations Could Muddle COVID-19 PCR Tests
Jack J. Lee | May 17, 2021
Researchers find that SARS-CoV-2 variants can evade primer-probe sets and recommend that diagnostic assays include multiple targets for reliability.
Millipore stock
Viral Nucleic Acid Purification in a Single Spin
The Scientist Creative Services Team, MilliporeSigma | Apr 6, 2022
A simple nucleic acid extraction approach quickly purifies genomic viral RNA and DNA while minimizing cross-contamination risks.
liquid-containing tube labeled Laboratory Test Wastewater Sample SARS-CoV-2
Sewage Sampling Robots Speed SARS-CoV-2 Detection
Ruth Williams | May 1, 2021
An automated wastewater monitoring technique could enable researchers to predict outbreaks of the virus up to a week in advance.
Infographic: How to Ferret Out SARS-CoV-2 in Sewage
Ruth Williams | May 1, 2021
Researchers use magnetic nanoparticles and liquid-handling robots in an effort to detect COVID-19 outbreaks early.
Quick and Reliable Plant DNA Extraction
Quick and Reliable Plant DNA Extraction
MilliporeSigma | Dec 22, 2021
An innovative, environmentally-friendly spin kit maximizes DNA isolation.
Dr. Brock standing in nature, holding a walking stick and wearing binoculars around his neck.
Microbiologist Thomas Brock Dies at 94
Lisa Winter | Apr 23, 2021
Brock’s discovery of a thermophile bacteria at Yellowstone National Park in 1966 eventually enabled the development of PCR.
rugby, concussion, brain injury, concussion, trauma, saliva, spit, test, noninvasive, diagnostic, microRNA, small noncoding RNA, PCR, RNA
Simple Spit Test Could Diagnose Concussions
Asher Jones | Mar 24, 2021
A noninvasive saliva test accurately identified concussions in a study of hundreds of rugby players.
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Thinking Digital: When qPCR Doesn’t Make the Cut
The Creative Services Team in collaboration with Bio-Rad Laboratories | Oct 20, 2021
Bio-Rad experts Eddy van Collenburg and Jörg Bantin will discuss where your research can greatly benefit from using ddPCR rather than qPCR, as well as how to ensure a seamless transition to ddPCR.
Breastmilk Harbors Antibodies to SARS-CoV-2
Ashley Yeager | Nov 17, 2020
An abundance of immunoglobulin antibodies, and a paucity of viral RNA, in breastmilk offer evidence that women can safely continue breastfeeding during the pandemic.
Toward COVID-19 Testing Any Time, Anywhere
Abby Olena | Sep 2, 2020
Researchers are adapting CRISPR, synthetic biology, and other creative approaches to detect SARS-CoV-2 nucleic acids outside of the lab or doctors’ offices, in the hopes of making diagnostics more affordable and accessible.
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Taking PCRs to the Next Level to Maximize Throughput and Target Amplification
The Scientist Creative Services Team in collaboration with Eppendorf | Oct 1, 2021
Thermal cycler innovations allow researchers to determine optimal annealing and denaturation temperatures in a single PCR run.    
university of illinois saliva test covid-19 sars-cov-2 rt-pcr campus screening coronavirus pandemic
U of Illinois Returns to School with 20,000 Saliva Tests Per Day
Emma Yasinski | Aug 28, 2020
The school requires each student, faculty, and staff member to be tested twice per week and sends the results straight to their cell phones.