The Scientist - Home

Researchers investigated how cancer antigenicity drives unique forms of T cell exhaustion and hypofunctionality.

Biogerontologist Matt Kaeberlein studies aging pets to determine how to improve healthspan in dogs and their humans.

By delivering mRNA to the skin of mice in utero, researchers showed a proof-of-concept for shuttling gene therapies to skin cells before birth.

Oncolytic viruses can help glioblastoma respond to immunotherapy.

Researchers created a new high-throughput tool to hunt for therapies that remyelinate the nervous system.

By editing a mutated immune regulatory gene in patient cells, Rosa Bacchetta brings hope to those suffering from IPEX syndrome.

Researchers track neural connections between retinal cells in a dish to understand their therapeutic potential.

By successfully creating transgenic ants for the first time, researchers discovered that danger-signaling pheromones activate a sensory hub in the ants’ brains.

Exercise drives the liver to produce the CES2 enzyme, which circulates in blood and delivers some of the benefits of exercise in mice. 

Researchers identified cold-adapted microbes that degrade certain plastics at low temperatures, potentially saving energy in industrial recycling.

Extra copies of four interferon receptor genes found on human chromosome 21 trigger developmental changes in a mouse model of Down syndrome.

Rebecca Shansky studies both female and male rodents to ensure that scientists have a complete and unbiased picture of the brain.