Brain Fog Caused by Long COVID and Chemo Appear Similar

Data from mouse models for mild coronavirus infections and human tissue samples offer further evidence that it doesn’t take a severe infection—or even infection of brain cells at all—to cause long-term neurological symptoms.

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| 6 min read
Artist’s rendering of brain fog: a bright blue drawing of a brain sits inside of a pink drawing of a head in profile surrounded by miscellaneous shapes

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As the coronavirus pandemic continues, scientists are racing to understand the underlying causes and implications of long COVID, the umbrella term for symptoms that persist for at least 12 weeks but often last even longer and affect roughly 30 percent of individuals who contract COVID-19. Evidence for specific risk factors such as diabetes and the presence of autoantibodies is starting to emerge, but throughout the pandemic, one assumption has been that an important indicator of whether a COVID-19 survivor is likely to develop long COVID is the severity of their acute illness.

However, a preprint shared online on January 10 suggests that even mild SARS-CoV-2 infections may lead to long-term neurological symptoms associated with long COVID such as cognitive impairment and difficulties with attention and memory, a suite of symptoms often lumped together as “brain fog.” In the study, which has not yet been peer-reviewed, scientists led by Stanford University ...

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Meet the Author

  • black and white image of young man in sunglasses with trees in background

    Dan Robitzski

    Dan is a News Editor at The Scientist. He writes and edits for the news desk and oversees the “The Literature” and “Modus Operandi” sections of the monthly TS Digest and quarterly print magazine. He has a background in neuroscience and earned his master's in science journalism at New York University.
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