Call for Germline Editing Moratorium

In response to speculation that groups have edited the DNA of human embryos, researchers request that gene editing of human reproductive cells be halted.

Written byJef Akst
| 2 min read

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Human eggWIKIMEDIA, ED UTHMANGene-editing technologies should not be used to edit human eggs, sperm, or embryos, Edward Lanphier, chairman of the Alliance for Regenerative Medicine in Washington, DC, and four other researchers argued in a Nature commentary published this week (March 12). Lanphier told MIT Technology Review that the statements he and his coauthors make in their comment reflects the views of his entire organization, which includes some 200 members and represents companies working on gene and cell therapy, including GE Healthcare and Johnson & Johnson.

“In our view, genome editing in human embryos using current technologies could have unpredictable effects on future generations,” Lanphier and his coauthors wrote. “This makes it dangerous and ethically unacceptable.” Moreover, they added, such techniques could potentially be used for nontherapeutic modifications, as implied by the headline of a recent MIT Technology Review article, “Engineering the Perfect Baby,” which noted that experiments involving the editing of human embryos are “pending publication.”

Fearing that such work could elicit “a public outcry” that would impede research involving the genetic editing of somatic cells, such as the work of Lanphier and his coauthors, the researchers called for the scientific to community to halt all work involving the editing of human reproductive cells. “Philosophically or ethically justifiable applications for ...

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  • Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.

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