Optogenetics is a technique that uses light to control the activity of cells that have been genetically modified to produce light-sensitive proteins. In a paper published in the November 1 issue of Cell, researchers report that inverting cell membrane–spanning, light-sensitive proteins in cells can change these proteins’ behavior, expanding the repertoire of ways in which scientists can manipulate neuronal activity.
J. Brown, “Expanding the optogenetics toolkit by topological inversion of rhodopsins,” Cell, 175:1131–40.e11, 2018
