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Serum is a vital ingredient that stabilizes and maintains good quality cell cultures by providing physiological and metabolic conditions that match in vivo biology. Fetal bovine serum (FBS) is the most widely used supplement in cultures because of its excellent growth-promoting ability. FBS provides a rich source of growth hormones, vitamins, trace elements, and proteins to cultured cells. In addition, FBS protects cultured cells by neutralizing potential toxic factors such as endotoxins, pH changes, and proteolytic activity.
FBS composition and quality significantly affect the health and behavior of cell cultures. Because serum is a biological product, manufacturers require stringent quality controls at the collection and distribution stages to develop an exceptional product. Serum manufacturers evaluate serum quality by testing osmolality and total protein content, and checking the presence of common contaminants.
Cell culture is indispensable in biological research, but it is expensive because of the high price of FBS. One ...
