ISTOCK, VKOVALCIK
Using a process called in situ vaccination, in which the host’s immune system is recruited to attack cancer cells, researchers were able to clear injected tumors—and nearby metastases—in mice, according to a study published yesterday (January 31) in Science Translational Medicine.
Scientists at Stanford University injected a pair of molecules—an antibody against a protein on the surface of T cells, known as OX40, and a short piece of DNA called a CpG oligodeoxynucleotide—into various types of solid tumors, including melanoma and breast and colon cancers, in mice. “When we use these two agents together, we see the elimination of tumors all over the body,” Ronald Levy, an oncologist at Stanford University, says in a statement. “This approach bypasses the need to identify tumor-specific immune targets ...
