Infographic: Neoantigen Prediction for Personalized Vaccine Design
Infographic: Neoantigen Prediction for Personalized Vaccine Design
See how a computational pipeline uses next-generation sequencing data to identify genetic alterations that produce cancer-specific antigens.
Infographic: Neoantigen Prediction for Personalized Vaccine Design
Infographic: Neoantigen Prediction for Personalized Vaccine Design

See how a computational pipeline uses next-generation sequencing data to identify genetic alterations that produce cancer-specific antigens.

See how a computational pipeline uses next-generation sequencing data to identify genetic alterations that produce cancer-specific antigens.

cancer vaccine
Personalized Cancer Vaccines in Clinical Trials
Personalized Cancer Vaccines in Clinical Trials
Jasreet Hundal, Elaine R. Mardis | Jul 15, 2019
The field is young, but predicting antigens produced by patients’ malignant cells could yield successful treatments for individuals with a range of cancer types.
Table: Personalized Cancer Vaccine Trials in the United States
Table: Personalized Cancer Vaccine Trials in the United States
Jasreet Hundal, Elaine R. Mardis | Jul 15, 2019
There are currently more than two dozen ongoing Phase 1 and Phase 2 trials using different vaccine platforms such as DNA, RNA, synthetic long peptides, and dendritic cells.
Cancer Vaxxer: A Profile of Miriam Merad
Cancer Vaxxer: A Profile of Miriam Merad
Anna Azvolinsky | Apr 1, 2019
The Mount Sinai oncologist studies innate immune cells with the goal of designing novel immunotherapies, including cancer vaccines.
New Ovarian Cancer Vaccine Shows Promise
New Ovarian Cancer Vaccine Shows Promise
Catherine Offord | Apr 12, 2018
A preliminary clinical trial finds that the personalized therapy improves survival rates and has no severe side-effects.
Stem Cell Vaccine Protects Mice From Cancer
Stem Cell Vaccine Protects Mice From Cancer
Ruth Williams | Feb 15, 2018
Stem cells and cancer cells have enough molecular similarities that the former can be used to trigger immunity against the latter.
Locally-Injected Immunotherapy Eradicates Tumors in Mice
Locally-Injected Immunotherapy Eradicates Tumors in Mice
Diana Kwon | Feb 1, 2018
The treatment also curbed the growth of nearby metastases that did not receive the drug.
Personalized Cancer Vaccines Show Promise for Melanoma
Personalized Cancer Vaccines Show Promise for Melanoma
Jef Akst | Jul 6, 2017
In two early trials, vaccines tailored to the mutations in individuals’ cancers appeared to protect 12 of 19 patients against relapse. 
Researchers Call for Retraction of Paper that Questions HPV Vaccine
Researchers Call for Retraction of Paper that Questions HPV Vaccine
Jef Akst | Dec 22, 2016
Oncologists have raised concerns about a mouse study that suggests the vaccine for human papillomavirus could cause brain damage.
Viral Immunotherapy for Melanoma
Viral Immunotherapy for Melanoma
Kerry Grens | May 28, 2015
Phase 3 data from a clinical trial show a positive response to a melanoma treatment based on a modified herpesvirus.
Personalized Cancer Vaccines
Personalized Cancer Vaccines
Anna Azvolinsky | Apr 2, 2015
A dendritic cell vaccine targeting melanoma patients’ tumor-specific mutations can activate a broad range of cancer-fighting T cells. 
Opinion: Making Cancer Vaccines Work
Opinion: Making Cancer Vaccines Work
Abhishek Srivastava and Haval Shirwan | Mar 30, 2015
Armed with the right adjuvant system, vaccines are poised to tackle one of the world’s most intractable diseases. 
Week in Review: June 23–27
Week in Review: June 23–27
Tracy Vence | Jun 26, 2014
Tracking chikungunya virus; reconsidering wood decay-based fungal classification; ASC specks spread inflammation; antibiotic tolerance in E. coli; RIKEN review yields corrections
Targeted Brain Cancer Vaccine
Targeted Brain Cancer Vaccine
Anna Azvolinsky | Jun 25, 2014
Mouse study demonstrates the ability of a cancer vaccine targeted against a specific oncogenic mutation to elicit a protective anti-tumor immune response. 
Deploying the Body’s Army
Deploying the Body’s Army
Jamie Green and Charlotte Ariyan | Apr 1, 2014
Using patients’ own immune systems to fight cancer
A Universal Cancer Vaccine?
Cristina Luiggi | Apr 10, 2012
A vaccine that targets 90 percent of all cancers shows promise in early clinical trials.
Cancer Immunotherapy Pioneer Dies
Edyta Zielinska | Dec 2, 2011
Lloyd Old, a researcher and former administrator of two cancer research institutes, passed away this week.
Pox Vaccine Treats Liver Cancer
Cristina Luiggi | Nov 11, 2011
A genetically engineered smallpox vaccine improved the survival of liver cancer patients participating in a phase II clinical trial.