Features

malaria feature
Are We Headed for a New Era of Malaria Drug Resistance?
Natalie Slivinski | Mar 1, 2019
Plasmodium falciparum has shown an ability to evade everything we throw at it, most recently artemisinin-based combination therapies, today’s front-line treatment.
viral brain feature the scientist
Can the Flu and Other Viruses Cause Neurodegeneration?
Ashley Yeager | Mar 1, 2019
Scientists may need to seriously reconsider the cast-aside hypothesis that pathogens can play a part in diseases such as Alzheimer’s and Parkinson’s.
Anesthesia drugs feature the scientist 2019
General Anesthesia Causes Telltale Brain Activity Patterns
Emery N. Brown, Francisco J. Flores | Mar 1, 2019
The drugs lead to widespread, predictable changes in brain waves that can help anesthesiologists personalize anesthesia and develop anesthetic-based treatments.

Contributors

march contributors the scientist
Contributors
Contributors
Meet some of the people featured in the March 2019 issue of The Scientist.

Editorial

anesthesia 2019 march editorial
Drugs, Developed
Drugs, Developed
In an era of instant communication, we must be careful how word of new and untested treatments is shared.

Speaking of Science

march 2019 crossword the scientist
Ten-Minute Sabbatical
Ten-Minute Sabbatical
Take a break from the bench to puzzle and peruse.

Notebook

A Lost Microbial World the scientist
Prehistoric Microbes Inhabit an Oasis in the Northern Mexican Desert
Prehistoric Microbes Inhabit an Oasis in the Northern Mexican Desert
The blue lagoons of the Cuatro Ciénegas Basin provide a glimpse into the planet’s ancient past.
drifting seabirds the scientist
GPS-Tagged Seabirds Track the Tides
GPS-Tagged Seabirds Track the Tides
Birds drifting on the surface of the sea could provide valuable data for oceanographers.
agouti mice Epigenetic Inheritance the scientist
Classic Mechanism of Epigenetic Inheritance Is Rare, Not the Rule
Classic Mechanism of Epigenetic Inheritance Is Rare, Not the Rule
A study suggests that the direct transfer of DNA methylation marks from one generation to the next is much less common than scientists previously thought.
Tibetan Plateau tools
Humans Made Tools Atop the Tibetan Plateau More than 30,000 Years Ago
Humans Made Tools Atop the Tibetan Plateau More than 30,000 Years Ago
A finding pushes back the timeline on humankind’s conquest of one of Earth’s harshest environments, and may provide clues about interactions with their hominin relatives.

Critic at Large

Modus Operandi

MO Microneedle patch mouse cells
Stick-On Immune Cell Monitor
Stick-On Immune Cell Monitor
A microneedle-containing skin patch offers researchers a noninvasive way to survey immune responses in mice.

The Literature

literature infographic dna repair
Without This Enzyme, Insertions Thrive in the Yeast Genome
Without This Enzyme, Insertions Thrive in the Yeast Genome
A study underscores the importance of Dna2 in maintaining the integrity of the genetic code.
RNA might have incorporated inosine, a derivative of adenosine, in place of guanosine
Primordial RNA May Have Contained Inosine
Primordial RNA May Have Contained Inosine
The discovery that the adenosine derivative aids self-replication adds weight to the theory that life on Earth originated from a mixture of RNA molecules.
archaea fused together with cytoplasmic bridges
Archaea CRISPR Systems Grab DNA Memories During Interspecies Mating
Archaea CRISPR Systems Grab DNA Memories During Interspecies Mating
When different archaeal species mate, their CRISPR systems interact in ways that may influence their evolution.

Profile

march 2019 the scientist profile
Master Decoder: A Profile of Kári Stefánsson
Master Decoder: A Profile of Kári Stefánsson
A neurologist by training, Stefánsson founded Iceland-based deCODE Genetics to explore what the human genome can tell us about disease and our species’ evolution.

Scientist to Watch

Emily Derbyshire scientist to watch
Emily Derbyshire Looks for Malaria’s Vulnerabilities
Emily Derbyshire Looks for Malaria’s Vulnerabilities
The Duke University professor studies the parasite to find a way to thwart infection before it takes hold.

Lab Tools

labtools march 2019 the scientist dna
The Challenge of Using CRISPR to Knock In Genes
The Challenge of Using CRISPR to Knock In Genes
Researchers are developing an array of techniques for accurately and efficiently inserting genes into DNA.

Careers

careers University of Oxford the scientist
Is Mandatory Retirement the Answer to an Aging Workforce?
Is Mandatory Retirement the Answer to an Aging Workforce?
For many, it’s not a question of when senior academics should leave their posts, it’s about how to distribute scarce resources such as grants and faculty positions more fairly.

Reading Frames

loonshots reading frames
In Praise of Crazy Ideas
In Praise of Crazy Ideas
The author of a new book explains the dangers of orthodoxy in science and beyond.

Foundations

nettie stevens x and y chromosome name origin the scientist
How Chromosomes X and Y Got Their Names, 1891
How Chromosomes X and Y Got Their Names, 1891
A quirk of nomenclature originates in the study of insect cells.

Infographics

malaria infographic
Infographic: Fighting Malaria Drug Resistance
Infographic: Fighting Malaria Drug Resistance
The parasite that causes malaria has evolved to evade many of the drugs that researchers have developed to fight the tropical disease.
brain virus infographic the scientist
Infographic: Viruses on the Brain
Infographic: Viruses on the Brain
Pathogens can take various routes to pass the blood brain barrier and damage cells.
anesthesia infographic the scientist
Infographic: How General Anesthesia Works
Infographic: How General Anesthesia Works
Drugs that doctors use to sedate patients during traumatic medical procedures act on neural receptors to alter brain activity.