Cover Story

How We Age
How We Age
The Scientist Staff | Mar 1, 2015
From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process.

Features

Wrangling Retrotransposons
Wrangling Retrotransposons
Andrei Seluanov, Michael Van Meter, Vera Gorbunova | Mar 1, 2015
These mobile genetic elements can wreak havoc on the genome. Researchers are now trying to understand how such activity contributes to the aging process.
Nourishing the Aging Brain
Nourishing the Aging Brain
Morten Scheibye-Knudsen | Mar 1, 2015
Research reveals how the brain changes as we age and hints at ways to slow the decline.

Contributors

Contributors

Contributors

Contributors

Meet some of the people featured in the March 2015 issue of The Scientist.

Editorial

Age-Old Questions

Age-Old Questions

Age-Old Questions

How do we age, and can we slow it down?

Speaking of Science

Speaking of Science

Speaking of Science

Speaking of Science

March 2015's selection of notable quotes

Notebook

Beneficial Stats

Beneficial Stats

Beneficial Stats

Statisticians who normally crunch numbers to forecast trends in the food-service industry turn their attention to bettering treatment of ALS.
A Deathly Pallor

A Deathly Pallor

A Deathly Pallor

Global warming could lead to lighter-colored insects with waning immune defenses.
Slip Me Some Skin

Slip Me Some Skin

Slip Me Some Skin

Scientists tracing the history of livestock breeding probe parchment documents for genetic information.
Falling Out of the Family Tree

Falling Out of the Family Tree

Falling Out of the Family Tree

A mutation in an ethanol-metabolizing enzyme arose around the time that arboreal primates shifted to a more terrestrial lifestyle, perhaps as an adaptation to eating fermented fruit.

Critic at Large

Sharing Longevity Data

Sharing Longevity Data

Sharing Longevity Data

Aging research would greatly benefit from consistently making annotated life span data available.
Quantity or Quality?

Quantity or Quality?

Quantity or Quality?

Living longer doesn’t necessarily mean living healthier.

Modus Operandi

Tricky Transfections

Tricky Transfections

Tricky Transfections

A combination of microinjection and electroporation inserts genes into hard-to-reach cells.

The Literature

Rethinking Telomeres

Rethinking Telomeres

Rethinking Telomeres

Not only do telomeres protect the ends of chromosomes, they also modulate gene expression over cells’ lifetimes.
Long Live Collagen

Long Live Collagen

Long Live Collagen

Increased collagen expression is a common feature of many different pathways to extended longevity in worms.
Growth Hormone Guidance

Growth Hormone Guidance

Growth Hormone Guidance

Intact growth hormone signaling pathways are needed for methionine restriction to extend mouse lifespan.

Profile

Of Cells and Limits

Of Cells and Limits

Of Cells and Limits

Leonard Hayflick has been unafraid to speak his mind, whether it is to upend a well-entrenched dogma or to challenge the federal government. At 86, he’s nowhere near retirement.

Scientist to Watch

Weiwei Dang: Epigenetics in Aging

Weiwei Dang: Epigenetics in Aging

Weiwei Dang: Epigenetics in Aging

Assistant Professor, Huffington Center On Aging, Baylor College of Medicine. Age: 38

Lab Tools

Chill GPS

Chill GPS

Chill GPS

Keeping track of frozen biological samples
Red Hot

Red Hot

Red Hot

CRISPR/Cas is all the rage—and getting more precise and efficient.

Careers

Riding Out Rejection

Riding Out Rejection

Riding Out Rejection

How to navigate the choppy waters of scientific publication

Reading Frames

Stirring the Pot

Stirring the Pot

Stirring the Pot

How to navigate the slings and arrows of conducting “controversial” research

Capsule Reviews

Capsule Reviews

Capsule Reviews

Capsule Reviews

Evolving Ourselves, The Man Who Touched His Own Heart, Bats, and The Invaders

Foundations

<em>Apiarium</em>, 1625

Apiarium, 1625

Apiarium, 1625

Galileo’s improvements to the microscope led to the first published observations using such an instrument.