A rendition of the bioinformatics analysis superimposed between two neurons. Combined with the METLIN metabolite database, the analysis ultimately revealed DMS as a naturally occurring metabolite and as an active molecule in chronic pain. GARY SIUZDAK AND GARY PATTI
An analysis of the metabolic profile of a rat model of chronic pain has identified novel dysregulated metabolites that may underlie the condition, according to a study published today (January 22) in Nature Chemical Biology. If the results hold up in humans, one of these metabolites, which has not previously been associated with neuropathic pain, could potentially serve as both a molecular indicator of and therapeutic target for the condition, for which few treatment options exist.
The findings are “a great example of how metabolomics is leading to novel insights into, in this case pain, and how that’s mediated,” said Lloyd Sumner, a metabolomics researcher at the Samuel Roberts Noble Foundation who was not involved in the research.
In the United States, more than 30 ...
