Most Comprehensive Analysis of Cancer Genomes to Date

An interrogation of the whole genomes of more than 2,600 cancers yields clues about the genetic drivers of malignancy, how tumors evolve, and more.

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The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Project published 23 papers today (February 5), including several in Nature, with insights from the genomes of more than 2,600 cancers of 38 tumor types.

“This study provides the most complete picture to date of cancer-causing mutations in all parts of the genome,” Pan-Cancer steering committee member Josh Stuart of the University of California, Santa Cruz, says in a press release. “It was a massive team science effort involving researchers spanning the globe.”

“To me, the most striking finding out of all of this . . . is just how different one person’s cancer genome is from another person’s,” says steering committee member Peter Campbell of the Wellcome Sanger Institute during a press conference, Fierce Biotech reports. “We see thousands of different combinations of mutations that can cause the cancer and more than 80 different underlying processes generating ...

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Meet the Author

  • Jef Akst

    Jef Akst was managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.
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