Fluorescent microscopy of a healthy intestinal organoid and a tumor spheroid
Internal Clock Disruptions Increase Colon Cancer Risk in Mice
Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.
Internal Clock Disruptions Increase Colon Cancer Risk in Mice
Internal Clock Disruptions Increase Colon Cancer Risk in Mice

Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.

Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.

cancer genomics
Artist’s 3D rendering of malignant cancer cells, illustrated in pink, as it would appear under a scanning electron microscope.
Underdog Enzyme Likely Responsible for Mutations in Most Cancers
Sophie Fessl | Jul 28, 2022
A previously overlooked enzyme called APOBEC3A is linked to the most prevalent mutational signatures in cancer cell lines, a study finds.
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
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The Scientist Speaks - Homing in on New Anticancer Targets 
Sejal Davla, PhD
Jason Sheltzer discusses cancer mechanisms leading to drug resistance and new approaches to find drug targets.
Illustration of light blue speckled DNA helix on a dark background
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Jef Akst | Apr 22, 2022
Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.
A compilation of several images, including a dog, a blind mole rat, and cell micrographs
Our Favorite Cancer Stories of 2021
Amanda Heidt | Dec 9, 2021
This year revealed just how much scientists have learned about the disease, from how animals become naturally cancer-resistant to how tumor cells harness extracellular DNA to develop rapid drug resistance.
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September 22, 2021 - Winning Westerns Technique Talk: Perfecting Western Blotting
The Scientist Creative Services Team in collaboration with Merck
Learn tips and tricks for optimizing Western blot experiments in this workshop.
man standing in front of gene sequencing machines
Q&A: Nearly Every Single Human Gene Can Be Linked to Cancer
Dan Robitzski | Oct 29, 2021
The Scientist spoke with University of Liverpool aging and longevity researcher João Pedro de Magalhães about how human biases can influence scientific priorities and outcomes in genetics.
Cancer May Be Driven by DNA Outside of Chromosomes
Paul Mischel | Apr 1, 2021
In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.
Most Comprehensive Analysis of Cancer Genomes to Date
Jef Akst | Feb 5, 2020
An interrogation of the whole genomes of more than 2,600 cancers yields clues about the genetic drivers of malignancy, how tumors evolve, and more.
MyHeritage Launches Health-Related Genetic Test, Ignites Debate
Catherine Offord | Jul 9, 2019
Its screen for selected variants of some disease-linked genes gives customers an incomplete picture of their risk—do they know?
Genetically Personalized Fruit Flies Screen for Cancer Drugs
Ruth Williams | May 22, 2019
Fly avatars bearing multiple genetic changes akin to those of a cancer patient lead to a tailor-made treatment that has shrunk the patient’s tumors.
Q&A: A 10,000-Genome Milestone for Shared Pediatric Cancer Data  
Carolyn Wilke | Apr 1, 2019
Computational biologist Jinghui Zhang of St. Jude realized scientists could work more efficiently with tools and genomic data shared on the cloud.
Hundreds of Inherited Gene Variants Contribute to Cancer
Abby Olena | Apr 5, 2018
In the largest study of its kind to date, researchers find more than 850 rare, heritable genetic alterations that can predispose humans to cancer.
Researchers Publish First Pan-Cancer Genomic Analyses in Pediatric Patients
Catherine Offord | Feb 28, 2018
Two large-scale studies reveal new insights into the genomic characteristics of childhood cancers.
Clarivate Ranks Most-Cited Researchers of 2017
Catherine Offord | Nov 15, 2017
China shows the biggest increase of any country in the number of scientists listed since last year, while cancer genomics emerges as one of the more dominant fields.
More than 18,000 Genomic Records from Cancer Patients Available
Kerry Grens | Jun 1, 2017
The publicly available database found nearly a third of samples included mutations targeted by either approved drugs or therapies in clinical trials. 
Angela Brooks: Splicing Specialist
Diana Kwon | Apr 1, 2017
At the University of California, Santa Cruz, the researcher combs the cancer genome, looking for weaknesses.
Cancer Genomes
The Scientist Staff | Mar 31, 2017
April Scientist to Watch Angela Brooks of the University of California, Santa Cruz, discusses her search to find vulnerabilities buried within the genomes of cancer cells.
AACR Q&A: Elaine Mardis
The Scientist Staff | Apr 18, 2016
The genomics pioneer shares the sessions she most looks forward to at this year’s American Association for Cancer Research annual meeting.