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2022 Top 10 Innovations
2022 Top 10 Innovations
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
2022 Top 10 Innovations
2022 Top 10 Innovations

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

cancer genomics
Pink- and purple-stained cells clustered into glands
Phenotypic Variation in Cancer Cells Often Not Due to Mutations
Jef Akst | Oct 26, 2022 | 3 min read
Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 
Fluorescent microscopy of a healthy intestinal organoid and a tumor spheroid
Internal Clock Disruptions Increase Colon Cancer Risk in Mice
Shafaq Zia | Aug 19, 2022 | 3 min read
Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.
800-x-560-sept-tss
The Scientist Speaks - Homing in on New Anticancer Targets 
Sejal Davla, PhD | 1 min read
Jason Sheltzer discusses cancer mechanisms leading to drug resistance and new approaches to find drug targets.
Artist’s 3D rendering of malignant cancer cells, illustrated in pink, as it would appear under a scanning electron microscope.
Underdog Enzyme Likely Responsible for Mutations in Most Cancers
Sophie Fessl, PhD | Jul 28, 2022 | 3 min read
A previously overlooked enzyme called APOBEC3A is linked to the most prevalent mutational signatures in cancer cell lines, a study finds.
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022 | 5 min read
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
36750-tsu-perfectingwesternblotting-ac-800x560
September 22, 2021 - Winning Westerns Technique Talk: Perfecting Western Blotting
The Scientist Creative Services Team in collaboration with Merck | 1 min read
Learn tips and tricks for optimizing Western blot experiments in this workshop.
Illustration of light blue speckled DNA helix on a dark background
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Jef Akst | Apr 22, 2022 | 2 min read
Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.
A compilation of several images, including a dog, a blind mole rat, and cell micrographs
Our Favorite Cancer Stories of 2021
Amanda Heidt | Dec 9, 2021 | 4 min read
This year revealed just how much scientists have learned about the disease, from how animals become naturally cancer-resistant to how tumor cells harness extracellular DNA to develop rapid drug resistance.
man standing in front of gene sequencing machines
Q&A: Nearly Every Single Human Gene Can Be Linked to Cancer
Dan Robitzski | Oct 29, 2021 | 6 min read
The Scientist spoke with University of Liverpool aging and longevity researcher João Pedro de Magalhães about how human biases can influence scientific priorities and outcomes in genetics.
Cancer May Be Driven by DNA Outside of Chromosomes
Paul Mischel | Apr 1, 2021 | 10+ min read
In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.
Most Comprehensive Analysis of Cancer Genomes to Date
Jef Akst | Feb 5, 2020 | 2 min read
An interrogation of the whole genomes of more than 2,600 cancers yields clues about the genetic drivers of malignancy, how tumors evolve, and more.
MyHeritage Launches Health-Related Genetic Test, Ignites Debate
Catherine Offord | Jul 9, 2019 | 8 min read
Its screen for selected variants of some disease-linked genes gives customers an incomplete picture of their risk—do they know?
Genetically Personalized Fruit Flies Screen for Cancer Drugs
Ruth Williams | May 22, 2019 | 4 min read
Fly avatars bearing multiple genetic changes akin to those of a cancer patient lead to a tailor-made treatment that has shrunk the patient’s tumors.
Q&A: A 10,000-Genome Milestone for Shared Pediatric Cancer Data  
Carolyn Wilke | Apr 1, 2019 | 3 min read
Computational biologist Jinghui Zhang of St. Jude realized scientists could work more efficiently with tools and genomic data shared on the cloud.
Hundreds of Inherited Gene Variants Contribute to Cancer
Abby Olena, PhD | Apr 5, 2018 | 3 min read
In the largest study of its kind to date, researchers find more than 850 rare, heritable genetic alterations that can predispose humans to cancer.
Researchers Publish First Pan-Cancer Genomic Analyses in Pediatric Patients
Catherine Offord | Feb 28, 2018 | 2 min read
Two large-scale studies reveal new insights into the genomic characteristics of childhood cancers.
Clarivate Ranks Most-Cited Researchers of 2017
Catherine Offord | Nov 15, 2017 | 2 min read
China shows the biggest increase of any country in the number of scientists listed since last year, while cancer genomics emerges as one of the more dominant fields.
More than 18,000 Genomic Records from Cancer Patients Available
Kerry Grens | Jun 1, 2017 | 2 min read
The publicly available database found nearly a third of samples included mutations targeted by either approved drugs or therapies in clinical trials. 
Angela Brooks: Splicing Specialist
Diana Kwon | Apr 1, 2017 | 3 min read
At the University of California, Santa Cruz, the researcher combs the cancer genome, looking for weaknesses.
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