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Conceptual illustration of personalized medicine with medical icons next to a human face.
The Largest Whole-genome Sequencing Study in Cancer 
Comprehensive genome sequencing of 13,880 tumors revealed somatic and germline mutations that could influence patient treatment and prognosis.
The Largest Whole-genome Sequencing Study in Cancer 
The Largest Whole-genome Sequencing Study in Cancer 

Comprehensive genome sequencing of 13,880 tumors revealed somatic and germline mutations that could influence patient treatment and prognosis.

Comprehensive genome sequencing of 13,880 tumors revealed somatic and germline mutations that could influence patient treatment and prognosis.

cancer genomics

The Evolution of Bats’ Super Immunity
Niki Spahich, PhD | Jan 10, 2024 | 4 min read
Researchers generated complete genomes of two important bat species and explored their immune- and cancer-related genes.
Epigenetic Changes Drive Cancer 
Rebecca Roberts, PhD | Nov 28, 2023 | 3 min read
An analysis of almost 700 different tumors revealed that DNA methylation drives tumorigenesis just like genetic mutations do. 
Defining the Triple Negative Breast Cancer Morpholome
Defining the Triple Negative Breast Cancer Morpholome
The Scientist Staff | 1 min read
Learn how researchers take a phenotype-first approach to uncover hidden metastatic drivers at tissue and cellular levels.
Microscopy image of blue stained cohesin proteins.
Mutated Cohesin Throws DNA Splicing out of Whack, Resulting in Cancer
Shafaq Zia | Mar 3, 2023 | 2 min read
Cohesin mutations cause dysregulations in alternative splicing, contributing to tumor initiation and progression, a study finds. 
Histological image of ccRCC
Mutational Signature Indicates Risk of Kidney Cancer Recurrence
Holly Barker, PhD | Mar 1, 2023 | 2 min read
DNA sequencing can identify mutations that predict recurrence of renal cell carcinoma and may help low-risk patients avoid unnecessary treatment, a study finds.
Layered visual representation of multiomics
Integrate and Innovate with NGS and Multiomics
The Scientist and Illumina | 6 min read
Researchers across disciplines combine layers of discovery obtained with accessible NGS-based multiomics approaches.
Red T cell
Jumping Genes Put a Target on Cancerous Cells
Natalia Mesa, PhD | Feb 14, 2023 | 4 min read
Two studies find that tumor-specific antigens are often peptides that result from a splicing event between exons and transposable elements.
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
Understanding How Single Cell Evolution Drives Tumor Complexity
Understanding How Single Cell Evolution Drives Tumor Complexity
The Scientist | 1 min read
Andris Abramenkovs and Mark Lynch will discuss how to overcome challenges obtaining high-definition genomic data from single cells.
Pink- and purple-stained cells clustered into glands
Phenotypic Variation in Cancer Cells Often Not Due to Mutations
Jef Akst | Oct 26, 2022 | 3 min read
Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 
Fluorescent microscopy of a healthy intestinal organoid and a tumor spheroid
Internal Clock Disruptions Increase Colon Cancer Risk in Mice
Shafaq Zia | Aug 19, 2022 | 3 min read
Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.
800-x-560-sept-tss
The Scientist Speaks - Homing in on New Anticancer Targets 
Sejal Davla, PhD | 1 min read
Jason Sheltzer discusses cancer mechanisms leading to drug resistance and new approaches to find drug targets.
Artist’s 3D rendering of malignant cancer cells, illustrated in pink, as it would appear under a scanning electron microscope.
Underdog Enzyme Likely Responsible for Mutations in Most Cancers
Sophie Fessl, PhD | Jul 28, 2022 | 3 min read
A previously overlooked enzyme called APOBEC3A is linked to the most prevalent mutational signatures in cancer cell lines, a study finds.
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022 | 5 min read
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
36750-tsu-perfectingwesternblotting-ac-800x560
September 22, 2021 - Winning Westerns Technique Talk: Perfecting Western Blotting
The Scientist Creative Services Team in collaboration with Merck | 1 min read
Learn tips and tricks for optimizing Western blot experiments in this workshop.
Illustration of light blue speckled DNA helix on a dark background
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Jef Akst | Apr 22, 2022 | 2 min read
Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.
A compilation of several images, including a dog, a blind mole rat, and cell micrographs
Our Favorite Cancer Stories of 2021
Amanda Heidt | Dec 9, 2021 | 4 min read
This year revealed just how much scientists have learned about the disease, from how animals become naturally cancer-resistant to how tumor cells harness extracellular DNA to develop rapid drug resistance.
man standing in front of gene sequencing machines
Q&A: Nearly Every Single Human Gene Can Be Linked to Cancer
Dan Robitzski | Oct 29, 2021 | 6 min read
The Scientist spoke with University of Liverpool aging and longevity researcher João Pedro de Magalhães about how human biases can influence scientific priorities and outcomes in genetics.
Cancer May Be Driven by DNA Outside of Chromosomes
Paul Mischel | Apr 1, 2021 | 10+ min read
In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.
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