cancer genomics

A new prime editing sensor library targeting p53 mutations allowed scientists to interrogate thousands of tumor genotypes as they arose in endogenous contexts.

Comprehensive genome sequencing of 13,880 tumors revealed somatic and germline mutations that could influence patient treatment and prognosis.

Learn how researchers take a phenotype-first approach to uncover hidden metastatic drivers at tissue and cellular levels.

Researchers generated complete genomes of two important bat species and explored their immune- and cancer-related genes.

An analysis of almost 700 different tumors revealed that DNA methylation drives tumorigenesis just like genetic mutations do. 

Researchers across disciplines combine layers of discovery obtained with accessible NGS-based multiomics approaches.

Researchers advance the potential of precision medicine with cutting edge sequencing technology.

Cohesin mutations cause dysregulations in alternative splicing, contributing to tumor initiation and progression, a study finds. 

DNA sequencing can identify mutations that predict recurrence of renal cell carcinoma and may help low-risk patients avoid unnecessary treatment, a study finds.

Andris Abramenkovs and Mark Lynch will discuss how to overcome challenges obtaining high-definition genomic data from single cells.

Two studies find that tumor-specific antigens are often peptides that result from a splicing event between exons and transposable elements.

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 

Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.

A previously overlooked enzyme called APOBEC3A is linked to the most prevalent mutational signatures in cancer cell lines, a study finds.

Learn where scientists need to exercise awareness when interpreting next-generation sequencing data for cancer screening.

Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.

Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.

Improving the reliability of genetic variant annotation and clinical interpretation