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Researchers in the UK and New Zealand have created the largest-ever database of protein expression changes associated with Alzheimer’s disease, according to a study published today (February 4) in Communications Biology. The data, which are freely available to researchers online, reveal new insights into the brain areas affected by Alzheimer’s, as well as the molecular pathways leading to the disease.
“This database provides a huge opportunity for dementia researchers around the world to progress and to follow-up new areas of biology and develop new treatments,” study coauthor Richard Unwin of the University of Manchester says in a statement. “It’s very exciting to be able to make these data public so scientists can access and use this vital information.”
The team analyzed the expression data of more than 5,500 proteins spanning six brain regions in postmortem tissue of nine healthy and nine Alzheimer’s-affected patients. The results provide ...
