PLOS ONE Pulls Five Papers Tied to Alzheimer’s Drug Controversy

The retracted studies were coauthored by a scientist who worked on an Alzheimer’s therapy in development by Cassava Sciences, a company reportedly under investigation for providing falsified data to the FDA.

Written byJef Akst
| 2 min read
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Update (July 27): The US Justice Department will investigate whether Cassava Sciences manipulated results pertaining to its experimental Alzheimer’s drug, sources tell Reuters, though neither the government nor the biotech has confirmed the launch of the investigation.

Five studies coauthored by Hoau-Yan Wang at the City University of New York and colleagues were pulled from PLOS ONE over concerns about data integrity yesterday (March 30), Retraction Watch reports. Wang, who already had another retraction to his name and who contributed to three other papers that have received expressions of concern, conducted research on an Alzheimer’s therapy called Simufilam that is under development by Austin, Texas–based Cassava Sciences (formerly Pain Therapeutics). Wang is also a paid advisor to the company, and Cassava employee Lindsay Burns is a coauthor on two of the newly retracted papers, which don’t pertain to Simufilam or Alzheimer’s disease.

Citing “people familiar with the matter,” The Wall ...

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  • Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.

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