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A purple-stained section of an invasive breast cancer growth. The dark purple non-fatty tissue takes up the majority of the frame, and pale purple circular tumors grow in ducts in the bottom left.

Harboring Hard and Soft Cells Lets Tumors Grow and Metastasize Simultaneously

Katherine Irving | Oct 17, 2022 | 4 min read

Islands of rigid cells within a matrix of soft ones allow tumors to be both solid and fluid, granting them toughness without losing the ability to break apart.

exterior of Fred Hutch research building

Fred Hutch Receives $710 Million Gift from the Bezos Family

Shawna Williams | Oct 13, 2022 | 1 min read

The donation will fund recruitment, research facilities, clinical research, and immunotherapy research.

From histopathology to multiplex immunohistochemistry and spatial transcriptomics, learn how to obtain the appropriate profiling depth to match cancer classification needs.

Broadening Tumor Molecular Profiling Horizons

Canopy Biosciences | 1 min read

From histopathology to multiplex immunohistochemistry and spatial transcriptomics, learn how to obtain the appropriate profiling depth to match cancer classification needs.

illustration of blue cells with exosomes budding off of them and floating away

Nanoparticles Spur Mouse Immune System to Attack Cancer

Shafaq Zia | Sep 13, 2022 | 2 min read

A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.

Renee Wegrzyn Tapped to Head ARPA-H

Andy Carstens | Sep 12, 2022 | 2 min read

As the new agency’s director, the DARPA veteran will spearhead a high-risk, high-reward approach to biomedical research.

A Brave New World for Spatial Genomics in Cancer Research

Nele Haelterman, PhD | 3 min read

A new CRISPR screening technology allows scientists to recreate tumor heterogeneity in vivo and study how it affects all aspects of cancer biology.

Histological slide showing cancerous prostate tissue

2D Genetic Map of Prostate Cells Charts Cancer Growth

Holly Barker | Aug 23, 2022 | 4 min read

An in situ map of copy number variations in prostate tissue reveals that purportedly cancerous genomic changes frequently occur in the healthy tissue surrounding tumors.

Monica Bertagnolli standing in a hallway

White House Names Monica Bertagnolli as NCI Director

Andy Carstens | Aug 10, 2022 | 2 min read

The announcement confirms earlier reports that Bertagnolli will become the first woman to lead the National Cancer Institute since its founding in 1937.

Setting Better Traps for PARP Inhibitors

The Scientist Creative Services Team and BPS Bioscience | 4 min read

An innovative assay permits researchers to screen for small molecule PARP inhibitors that trap the enzyme on DNA and selectively execute cancer cells.

black-and-white brain scan showing tumor

Glioblastoma Cells Imitate Immature Neurons to Invade the Brain

Sophie Fessl, PhD | Aug 5, 2022 | 3 min read

Neuron-like glioblastoma cells are the pioneers of deadly tumors’ spread through the brain, contributing to their devastating invasiveness, a study in mice finds.

Artist’s 3D rendering of malignant cancer cells, illustrated in pink, as it would appear under a scanning electron microscope.

Underdog Enzyme Likely Responsible for Mutations in Most Cancers

Sophie Fessl, PhD | Jul 28, 2022 | 3 min read

A previously overlooked enzyme called APOBEC3A is linked to the most prevalent mutational signatures in cancer cell lines, a study finds.

Enhancing the Efficacy of CAR-T Cell Therapies

The Scientist Creative Services Team in Collaboration with IsoPlexis | 1 min read

Jessica Morris will discuss strategies to improve CAR-T cell targeting, activation, and killing capabilities.

An illustration of a mitochondrion, represented by a purple and orange bilayer, synthesizing reddish molecules of ATP.

Mitochondrial Protein Fuels Spread of Head and Neck Cancer

Patience Asanga | Jul 8, 2022 | 3 min read

Head and neck cancer cells lacking the peptide involved in energy production were less likely to metastasize in mice.

Artist’s rendition of metastatic cancer cells with yellow nuclei and green cell bodies extending into blue tendrils.

While the Body Rests, Breast Cancer Spreads More Aggressively

Alejandra Manjarrez, PhD | Jun 23, 2022 | 4 min read

More cancer cells are shed from primary tumors when individuals are asleep than when they’re awake, according to observations in mouse models and a small cohort of breast cancer patients.

Best of Cancer Research

The Scientist Creative Services Team | 1 min read

This collection of articles from The Scientist explores some of the latest cancer research!

3D rendering of a scanning electron micrograph of pink malignant cancer cells against a black background

Cancers Ramp Up Overall mRNA Expression as They Progress

Dan Robitzski | Jun 14, 2022 | 4 min read

A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.

Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments

Ryan Layer, The Conversation | May 27, 2022 | 5 min read

Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.

Genetic and Spatial Heterogeneity in Human Papillomavirus-Associated Oropharyngeal Cancer

The Scientist Creative Services Team | 1 min read

Joseph Powell will discuss how heterogeneous subpopulations of HPV+ head and neck cancer cells drive unique disease states, cell-cell interactions, and microenvironment dynamics, and have implications for cancer behavior, metastasis, and response to treatment.

Man in lab coat sitting at a lab bench looking at small, stoppered beaker.

Cancer Researcher Donald Pinkel Dies at Age 95

Natalia Mesa, PhD | Mar 18, 2022 | 3 min read

Unsatisfied by how treatments for childhood leukemia failed to prevent the disease’s return, Pinkel combined them all—and virtually cured the disease.