illustration of blue cells with exosomes budding off of them and floating away
Nanoparticles Spur Mouse Immune System to Attack Cancer
A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.  
Nanoparticles Spur Mouse Immune System to Attack Cancer
Nanoparticles Spur Mouse Immune System to Attack Cancer

A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.  

A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.  

cancer research
woman smiling at camera
Renee Wegrzyn Tapped to Head ARPA-H
Andy Carstens | Sep 12, 2022
As the new agency’s director, the DARPA veteran will spearhead a high-risk, high-reward approach to biomedical research.
Histological slide showing cancerous prostate tissue
2D Genetic Map of Prostate Cells Charts Cancer Growth
Holly Barker | Aug 23, 2022
An in situ map of copy number variations in prostate tissue reveals that purportedly cancerous genomic changes frequently occur in the healthy tissue surrounding tumors.
From histopathology to multiplex immunohistochemistry and spatial transcriptomics, learn how to obtain the appropriate profiling depth to match cancer classification needs.
Broadening Tumor Molecular Profiling Horizons
Canopy Biosciences
From histopathology to multiplex immunohistochemistry and spatial transcriptomics, learn how to obtain the appropriate profiling depth to match cancer classification needs.
Monica Bertagnolli standing in a hallway
White House Names Monica Bertagnolli as NCI Director
Andy Carstens | Aug 10, 2022
The announcement confirms earlier reports that Bertagnolli will become the first woman to lead the National Cancer Institute since its founding in 1937.
black-and-white brain scan showing tumor
Glioblastoma Cells Imitate Immature Neurons to Invade the Brain
Sophie Fessl | Aug 5, 2022
Neuron-like glioblastoma cells are the pioneers of deadly tumors’ spread through the brain, contributing to their devastating invasiveness, a study in mice finds.
spatial CRISPR screen for cancer
A Brave New World for Spatial Genomics in Cancer Research
Nele Haelterman, PhD
A new CRISPR screening technology allows scientists to recreate tumor heterogeneity in vivo and study how it affects all aspects of cancer biology.
Artist’s 3D rendering of malignant cancer cells, illustrated in pink, as it would appear under a scanning electron microscope.
Underdog Enzyme Likely Responsible for Mutations in Most Cancers
Sophie Fessl | Jul 28, 2022
A previously overlooked enzyme called APOBEC3A is linked to the most prevalent mutational signatures in cancer cell lines, a study finds.
An illustration of a mitochondrion, represented by a purple and orange bilayer, synthesizing reddish molecules of ATP.

Mitochondrial Protein Fuels Spread of Head and Neck Cancer 

Patience Asanga | Jul 8, 2022
Head and neck cancer cells lacking the peptide involved in energy production were less likely to metastasize in mice.
Human DNA stock photo
Setting Better Traps for PARP Inhibitors
The Scientist Creative Services Team and BPS Bioscience
An innovative assay permits researchers to screen for small molecule PARP inhibitors that trap the enzyme on DNA and selectively execute cancer cells.
Artist’s rendition of metastatic cancer cells with yellow nuclei and green cell bodies extending into blue tendrils.
While the Body Rests, Breast Cancer Spreads More Aggressively
Alejandra Manjarrez | Jun 23, 2022
More cancer cells are shed from primary tumors when individuals are asleep than when they’re awake, according to observations in mouse models and a small cohort of breast cancer patients.
3D rendering of a scanning electron micrograph of pink malignant cancer cells against a black background
Cancers Ramp Up Overall mRNA Expression as They Progress
Dan Robitzski | Jun 14, 2022
A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.
Enhancing the Efficacy of CAR-T Cell Therapies
The Scientist Creative Services Team in Collaboration with IsoPlexis
Jessica Morris will discuss strategies to improve CAR-T cell targeting, activation, and killing capabilities.
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
Man in lab coat sitting at a lab bench looking at small, stoppered beaker.
Cancer Researcher Donald Pinkel Dies at Age 95
Natalia Mesa | Mar 18, 2022
Unsatisfied by how treatments for childhood leukemia failed to prevent the disease’s return, Pinkel combined them all—and virtually cured the disease.
Best of Cancer Research
The Scientist Creative Services Team
This collection of articles from The Scientist explores some of the latest cancer research!
Salmonella (pink) invading a human epithelial cell (yellow)
Modified Salmonella Revs Immune Response, Combats Tumors in Mice
Natalia Mesa | Feb 3, 2022
When coated with positively charged particles, the bacteria shuttled antigens out of tumors and activated the immune system, a study finds.
Photo of older woman dressed in blue smiling and looking at the camera
Cancer Researcher Beatrice Mintz Dies at 100
Natalia Mesa | Jan 20, 2022
Mintz’s experiments over her six-decade career were foundational to cancer and genetics research.
Genetic and Spatial Heterogeneity in Human Papillomavirus-Associated Oropharyngeal Cancer
The Scientist Creative Services Team
Joseph Powell will discuss how heterogeneous subpopulations of HPV+ head and neck cancer cells drive unique disease states, cell-cell interactions, and microenvironment dynamics, and have implications for cancer behavior, metastasis, and response to treatment.   
black-and-white image of an open mouth
The Common Mouth Microbe That Keeps Popping Up in Tumors
David Adam | Dec 15, 2021
Lab studies link the oral bacteria Fusobacterium nucleatum to cancers from the gut to the head and neck. Could targeting the microbe tackle tumors?