Zebrafish with parts of nervous system in green.
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development
The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.
ABOVE: Marko Pende, Science Advances
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development

The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.

The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.

ABOVE: Marko Pende, Science Advances

drug design

An orange CRISPR Cas 9 enzyme cutting DNA
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa | Mar 2, 2022
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
3D illustration of a tapeworm infestation in a human intestine
Return of the Worms
Catherine Offord | Dec 1, 2021
Immunologists and parasitologists are working to revive the idea that helminths, and more specifically the molecules they secrete, could help treat allergies and autoimmune disease.
Transforming Virology Research with Cryo-EM
The Scientist Creative Services Team, Thermo Fisher Scientific | May 11, 2021
Explore what researchers can do with Cryo-EM
December 2021 - Gut Guests - Infographic
Infographic: How Worms that Reside in the Gut Could Influence Health
Catherine Offord | Dec 1, 2021
Research in animals and people supports a range of mechanisms by which the parasites affect physiology and immune responses.
neutrobots, neutrophils, white blood cells, microrobots, nanorobots, microbots, glioma, brain cancer, paclitaxel, magnetic, swarm, mice
Microscopic Robots Deliver Drugs to the Brain
Asher Jones | Mar 30, 2021
Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.
Activities Discovered for Some Inactive Drug Ingredients
Ruth Williams | Jul 23, 2020
Screens of hundreds of drug excipients reveal that some can interact with biological targets, contradicting their FDA categorization as inert.
Infographic: Building Bacteria to Fight Cancer
Simone Schuerle, Tal Danino | Apr 1, 2020
Researchers are engineering microbes to deliver therapeutics specifically to tumors, maximizing the treatments’ efficacy while minimizing side effects.
Bacteria as Living Microrobots to Fight Cancer
Simone Schuerle, Tal Danino | Apr 1, 2020
Autonomous, living microrobots that seek and destroy cancer are not as futuristic as one might imagine, thanks to a fusion of robotics and synthetic biology.
Amyloid Designed to Inactivate Cancer-Related Protein
Kerry Grens | Nov 13, 2016
Researchers build a peptide that causes a receptor to form toxic, amyloid-like clumps in cells.
Anticipating Resistance
Jyoti Madhusoodanan | Feb 16, 2015
Using computational algorithms and experimental evolution, researchers are predicting antimicrobial-resistance patterns to improve drug design. 
Chemistry as Art
Abby Olena | Jan 31, 2014
See Scientist To Watch Phil Baran describe the artistry of his research in drug discovery.