Infographic showing how neurodegenerative diseases have long been associated with aggregations of apparently toxic proteins
Infographic: Secret Lives of Neurodegeneration-Linked Proteins
Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.
Infographic: Secret Lives of Neurodegeneration-Linked Proteins
Infographic: Secret Lives of Neurodegeneration-Linked Proteins

Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.

Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.

Parkinson's disease
Amyloid plaques on axons of neurons
The Misunderstood Proteins of Neurodegeneration
Catherine Offord | Aug 1, 2022
The normal functions of peptides that aggregate in Alzheimer’s, Parkinson’s, and Huntington’s have been largely overlooked by scientists, but some argue that they are critical for understanding the development of disease.
3D illustration showing neurons inside the brain
Experimental Pill to Treat Parkinson’s Is Safe, Trial Finds
Andy Carstens | Jun 10, 2022
Testing in animals and lab-grown cells suggests the experimental drug could enhance the function of lysosomes within cells.
Autophagy and Mitophagy in Neurodegeneration: A Deep Dive
Autophagy and Mitophagy in Neurodegeneration: A Deep Dive
The Scientist Creative Services Team and PerkinElmer
Robin Ketteler and Hélène Plun-Favreau discuss the importance of autophagy and mitophagy regulation in neurodegenerative diseases.
A pink and blue illustration of the central nervous system, visible through a translucent outline of a human head and shoulders, zooms in to show an illustration of interconnected neurons
Specific Brain Cells Linked to Parkinson’s Disease
Dan Robitzski | May 6, 2022
Research identifies 10 types of dopamine-making neurons, one of which seems to die off during the disease.
Photo of Ana Marija Jakšic
Ana Marija Jakšić Shapes Fruit Fly Brains
Chloe Tenn | Apr 18, 2022
The Swiss Federal Institute of Technology Lausanne evolutionary neurobiologist is using Drosophila to investigate how organisms adapt to novel environments.
Stem Cell Transplant Treats Parkinson’s Disease in Monkeys
Roni Dengler, PhD
Personalized stem cells improved motor symptoms and depression signs in monkeys modeling Parkinson’s disease, paving the way for trials in human patients.
Bespectacled man wearing black shirt with arms folded looks at camera in front of lab cabinet
Neuropathologist John Trojanowski Dies at 75
Lisa Winter | Mar 18, 2022
His work was pivotal to understanding the mechanisms of neurodegenerative diseases, particularly Alzheimer’s and Parkinson’s.
Translucent, red-orange organs are shown inside a person’s transparent, blue torso. One region zooms in on blue lung alveoli covered by bright orange microbes.
Bacteria in the Lungs Can Regulate Autoimmunity in Rat Brains
Dan Robitzski | Mar 17, 2022
Making specific alterations to the bacterial population in a rat’s lungs either better protects the animals against multiple sclerosis–like symptoms or makes them more vulnerable, a study finds—the first demonstration of a lung-brain axis.
Scientific Breakthroughs with Cryogenic Electron Microscopy
The Scientist Creative Services Team and Thermo Fisher Scientific
Structures made via cryo-EM give researchers insights into SARS-CoV-2, HIV, neurological disorders, cancer, and more.
An illustration of a yeast cell (right) and a human neuron (left) showing the processes/features that are similar in the two
Infographic: Modeling Neurodegenerative Diseases with Yeast
Mahlon Collins | Oct 1, 2021
Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.
Photographs of the October 2021 issue's contributors
Contributors
The Scientist Staff | Oct 1, 2021
Meet some of the people featured in the October 2021 issue of The Scientist.
How Infectious Diseases Affect the Brain
The Scientist Creative Services Team
From a loss of taste to dementia, infectious agents cause an array of neurological symptoms.
Scanning electron micrograph (SEM) of the unicellular yeast Saccharomyces cerevisiae, known as Baker's or Brewer's yeast.
Yeast Models Provide New Insights into Neurodegenerative Diseases
Mahlon Collins | Oct 1, 2021
The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.
Astrocyte-to-Neuron Method Reverses Neurodegeneration in Mice
Ruth Williams | Jun 24, 2020
The cell conversion strategy restores neurons and motor functions lost as a result of an induced Parkinson’s-like illness in the animals.
The Scientist Speaks Ep. 16 - At the Breaking Point: Mitochondrial Deletions and the Brain
The Scientist Creative Services Team
Researchers characterize large mitochondrial deletions to understand their implications in neurological disorders.
pharmacology medicine parkinson's disease dopamine l-dopa levodopa Hornykiewicz obituary
Oleh Hornykiewicz, Who Pioneered Treatment for Parkinson’s, Dies
Amanda Heidt | Jun 18, 2020
The University of Toronto and University of Vienna pharmacologist developed L-dopa, a precursor to dopamine that remains the most widely used therapy for Parkinson’s disease.
A Citizen Scientist Makes Her Mark in Microbiome Research
Amy Schleunes | Jun 1, 2020
The BioCollective, a company that transforms whole stool samples into microbial metadata, is developing the US’s first national microbiome reference material.
Breaking Down Barriers
The Scientist Creative Services Team
Looking at the future of neurodegeneration research!
Into the Light: A Profile of Joanne Chory
Emily Makowski | Mar 1, 2020
The plant geneticist has revolutionized researchers’ understanding of how light affects plant growth and development, and is engineering plants to combat climate change.