Illustration of light blue speckled DNA helix on a dark background
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.
ABOVE: © ISTOCK.COM, KOTO_FEJA
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Study Nearly Doubles Known Cancer-Linked Mutational Signatures

Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.

Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.

ABOVE: © ISTOCK.COM, KOTO_FEJA

precision medicine

A vial containing a red blood sample is balanced on its end on a table or desk by someone wearing a blue medical glove on their right hand
New Evidence Shows COVID-19 Was in US Weeks Before Thought
Abby Olena | Jun 17, 2021
Some of the blood specimens collected in the United States for the NIH’s All of Us research program starting on January 2, 2020, have antibodies against SARS-CoV-2.
smart pills
Smart Pills Help Monitor Cancer Patients’ Therapy
Chia-Yi Hou | Jul 15, 2019
Sensors encapsulated with oral chemotherapy drugs help patients and physicians keep track of treatments.
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Can mRNA Vaccine Momentum Propel Tumor Immunotherapies?
Aparna Nathan | Nov 12, 2021
A guide to mRNA-based cancer vaccines and where they’re headed next
Contributors july august the scientist
Contributors
The Scientist Staff | Jul 15, 2019
Meet some of the people featured in the July/August 2019 issue of The Scientist.
Opinion: Applying AI to Clinical Care Is Key to Individualized Medicine
Opinion: Applying AI to Clinical Care Is Key to Individualized Medicine
Eric Topol | Jul 15, 2019
Not only can artificial intelligence revolutionize healthcare, it could help restore the doctor-patient relationship.
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Precision Medicine Turns to Proteins for Lung Cancer Targets
Roni Dengler, PhD | Nov 9, 2021
Probing the protein landscape in lung cancers reveals new therapeutic insights.
3-D Treatment
Tumor Organoids Hold Promise for Personalizing Cancer Therapy
Jef Akst | Jul 15, 2019
The three-dimensional cell cultures are still in the development phase, but researchers are excited about their use to predict patients’ responses to various treatment options.
Topol on Deep Medicine
The Scientist Staff | Jul 15, 2019
Eric Topol, founder and director of Scripps Research Translational Institute and Reading Frames author, discusses the future of the doctor-patient bond in an era of artificial intelligence–driven medicine.
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The Scientist Speaks - Homing in on New Anticancer Targets 
Sejal Davla, PhD | Sep 28, 2021
Jason Sheltzer discusses cancer mechanisms leading to drug resistance and new approaches to find drug targets.
Orkin on Childhood Cancer
The Scientist Staff | Jul 15, 2019
This month’s Profilee, Dana-Farber Cancer Institute researcher Stuart Orkin, talks about treating kids with cancer and other blood disorders.
Startups Plan the Health Data Gold Rush
Shawna Williams | Oct 1, 2018
Companies are building platforms based on blockchain technology to let individuals control and directly profit from their genomic and medical information.
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A New Model with Fully Functioning Blood Vessels Mimics Brain Cancer
Roni Dengler, PhD | Sep 10, 2021
A newly developed platform may one day replace cell culture and animal models to personalize cancer treatment.
FDA Approves Oral Drug for Fabry Disease
Ashley Yeager | Aug 13, 2018
The medicine increases the activity of a deficient enzyme in certain patients with the condition.
Companies to Help People Sell or Rent Out Their Health Data
Catherine Offord | Jun 5, 2018
Luna DNA, Nebula Genomics, and other “bio-brokers” will allow customers to make money by granting access to their genetic and personal information for research purposes.
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The Scientist Speaks - The Reality of Regenerative Medicine
The Scientist Creative Services Team | Aug 26, 2021
After decades of research the potential of regenerative medicine becomes a life-saving reality.
NIH Plans to Enroll 1 Million People for Health Database
Catherine Offord | May 3, 2018
The agency says it has taken various steps to ensure the privacy of participants’ data. 
New Ovarian Cancer Vaccine Shows Promise
Catherine Offord | Apr 12, 2018
A preliminary clinical trial finds that the personalized therapy improves survival rates and has no severe side-effects.
Measuring Metabolites to Prevent, Diagnose, and Treat Cancer
Niki Spahich, PhD | Jun 11, 2021
Metabolomics research highlights molecules important for cancer prevention, diagnosis, and treatment.
More than 18,000 Genomic Records from Cancer Patients Available
Kerry Grens | Jun 1, 2017
The publicly available database found nearly a third of samples included mutations targeted by either approved drugs or therapies in clinical trials.