A false-colored micrograph showing swirls of yellow, red, and magenta cells
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Cross-Resistance: One Cancer Therapy Can Undermine the Next

Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.

Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.

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signaling pathways

High Stress Hormone Levels Halt Mouse Fur Growth
Jef Akst | Apr 1, 2021
Corticosterone interferes with signaling in the skin that normally activates hair follicle stem cells, possibly explaining the link between stress and hair loss.
Kathryn Anderson, forward genetics, genetics & genomics, model organisms, Toll, hedgehog, embryogenesis, developmental biology, cell differentiation, cilia,
Developmental Biologist Kathryn Anderson Dies at 68
Amanda Heidt | Jan 6, 2021
The Sloan Kettering researcher used mutagenic screening to probe genes and molecular pathways, including Toll and Hedgehog, essential to development in fruit flies and mice.
The Structure and Functions of the p53 Pathway: Information Acquisition, Redundancy, and Connectivity
The Scientist Creative Services Team | Jun 5, 2020
Arnold Levine will discuss his discovery of p53 and the evolution of the field since then, and Jon Chen will discuss the use of single-cell phosphoproteomics in identifying changes in key signaling networks, including p53.
Compounds from Smoke Alter Root Development in Plants
Shawna Williams | Mar 1, 2020
Defects in the response to fire-generated karrikins turn out to be responsible for root anomalies that were previously ascribed to other plant hormones.
Into the Light: A Profile of Joanne Chory
Emily Makowski | Mar 1, 2020
The plant geneticist has revolutionized researchers’ understanding of how light affects plant growth and development, and is engineering plants to combat climate change.
Japanese grass pufferfish (Takifugu niphobles) CT scan
Pufferfish Spines Shaped by Same Genes as Feathers and Fish Scales
Nicoletta Lanese | Jul 29, 2019
To see if the spiky fish shares signaling pathways found in other organisms, scientists scooped up specimens during a mating frenzy on the shores of Japan.
Bacterial Cell Envelope Size is Key to Membrane Stress Response
Diana Kwon | Mar 1, 2018
Transmission of stress signals in E. coli is dependent on the distance between its inner and outer membranes.
Your Body Is Teeming with Weed Receptors
Megan Scudellari | Jul 16, 2017
And the same endocannabinoid system that translates marijuana's buzz-inducing compounds into a high plays crucial roles in health and disease outside the brain.
Endocannabinoids in the Groove
Megan Scudellari | Jul 16, 2017
The system responsible for the buzz humans get from marijuana plays a passel of physiological roles outside the brain.
Professional Marksman
Anna Azvolinsky | Apr 1, 2015
Charles Sawyers, who began his research career just as the genetic details of human oncogenes were emerging, codeveloped Gleevec, the quintessential targeted cancer therapy.