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Monitoring Mutations with Microfluidics
Ruth Williams | Mar 15, 2018
A device dubbed the “mother machine” enables real-time observation of mutagenesis in single bacterial cells.
Thousands of Mutations Accumulate in the Human Brain Over a Lifetime
Ruth Williams | Dec 7, 2017
Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death.
Catalog of the Small Intestine Reveals New Cell Subtypes
Kerry Grens | Nov 8, 2017
Single-cell analyses from mouse samples detail the changes in cell distribution during infections.
Live Cell Extractions
Ruth Williams | Oct 1, 2017
Nanostraws that collect specimens from cells without killing them allow for repeated sampling.
Mini-Metagenomics Leads to Microbial Discovery
Abby Olena | Jul 14, 2017
Researchers develop a method that combines the strengths of shotgun metagenomics and single-cell genome sequencing in a microfluidics-based platform.
Massively Parallel Perturbations
Ruth Williams | Mar 1, 2017
Scientists combine CRISPR gene editing with single-cell sequencing for genotype-phenotype screens.
Infographic: Single-Cell CRISPR Screens
Ruth Williams | Feb 28, 2017
See how two new methods track responses to unique genetic manipulations in numerous individual cells in parallel.
Using Raman Spectroscopy to Identify Cell Types
Jyoti Madhusoodanan | Dec 1, 2016
Improvements in instruments and statistical tools allow the capture and analysis of large data sets.
Top 10 Innovations 2016
Staff | Dec 1, 2016
This year’s list of winners celebrates both large leaps and small (but important) steps in life science technology.
Single-Cell RNA Sequencing Reveals Neuronal Diversity
Catherine Offord | Jun 23, 2016
Using a new approach to analyze the transcriptomes of thousands of individual cell nuclei in postmortem brains, researchers identify multiple neuronal subtypes.