Limited Meal Times Prevent Obesity in Mice Prone to Gaining Weight

Even in mice with a busted circadian clock and an unhealthy diet, carefully timed feeding overcomes the rodents’ predispositions for metabolic diseases.

abby olena
| 3 min read

DRA_SCHWARTZ, ISTOCK

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Mice with faulty circadian clocks are prone to obesity and diabetes. So are mice fed a diet high in fat. Remarkably, animals that have both of these obesity-driving conditions can stay lean and metabolically healthy by simply limiting the time of day when they eat. In a study published today (August 30) in Cell Metabolism, researchers report that restricting feeding times to mice’s active hours can overcome both defective clock genes and an unhealthy diet, a finding that may have an impact in the clinic.

The work corroborates previous research showing how powerful restricted feeding can be to improve clock function, says Kristin Eckel-Mahan, a circadian biologist at the University of Texas Health Science Center at Houston who did not participate in the study. Over the last 20 years, biologists have found circadian clocks keeping physiologic time in almost every organ. They have also shown that mice with disrupted clocks ...

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  • abby olena

    Abby Olena, PhD

    As a freelancer for The Scientist, Abby reports on new developments in life science for the website.
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