Cover Story

Deploying the Body’s Army
Deploying the Body’s Army
Jamie Green and Charlotte Ariyan | Apr 1, 2014
Using patients’ own immune systems to fight cancer

Features

Overcoming Resistance
Overcoming Resistance
The Scientist Staff | Apr 1, 2014
In the face of bacterial threats that can evade modern medicines, researchers are trying every trick in the book to develop new, effective antibiotics.
Metals on our Mind
Metals on our Mind
Anthony White | Apr 1, 2014
A dramatic loss of copper in key brain regions may be central to Alzheimer’s disease. Could restoring metals in the brain help?

Contributors

Contributors
Contributors
Contributors
Meet some of the people featured in the April 2014 issue of The Scientist.

Editorial

Search and Destroy
Search and Destroy
Search and Destroy
Turning a patient’s immune cells into cancer-fighting weapons

Speaking of Science

Speaking of Science
Speaking of Science
Speaking of Science
April 2014's selection of notable quotes

Notebook

Fluke Forces
Fluke Forces
Fluke Forces
Dolphins prove that they rely on muscle power, rather than a trick of fluid dynamics, to race through water at high speeds.
Getting Down to Business
Getting Down to Business
Getting Down to Business
Is there a genetic component to entrepreneurial success?
Have Herpes, Will Travel
Have Herpes, Will Travel
Have Herpes, Will Travel
Insight into the geographical clustering of a viral genome comes from an unexpected source.
Dermatologically Derived
Dermatologically Derived
Dermatologically Derived
Inspired by turkey skin, researchers devise a bacteriophage-based sensor whose color changes upon binding specific molecules.

Critic at Large

Fighting Cancer with Nanomedicine
Fighting Cancer with Nanomedicine
Fighting Cancer with Nanomedicine
Nanotechnology-based therapeutics will revolutionize cancer treatment.
Stem Cells Off the Line
Stem Cells Off the Line
Stem Cells Off the Line
Researchers work to improve the efficiency of cell therapy manufacturing, while developing procedures to ensure consistent quality.    
 

Modus Operandi

Molecular Multitasker
Molecular Multitasker
Molecular Multitasker
Scientists create a way to isolate mRNA from a single living cell within a tissue.

The Literature

Going Long
Going Long
Going Long
Researchers discover a tool to trigger an uncommon strategy cancer cells can use to lengthen their telomeres.
Elusive Receptor ID’d
Elusive Receptor ID’d
Elusive Receptor ID’d
Scientists identify an extracellular ATP receptor in plants.
Stem Cell Alter Egos
Stem Cell Alter Egos
Stem Cell Alter Egos
Researchers show that cancer stem cells can exist in two distinct and interconvertible states.

Profile

Commander of an Immune Flotilla
Commander of an Immune Flotilla
Commander of an Immune Flotilla
With much of his early career dictated by US Navy interests, Carl June drew inspiration from malaria, bone marrow transplantation, and HIV in his roundabout path to a breakthrough in cancer immunotherapy.

Scientist to Watch

Maria Spies: Molecular Machinist
Maria Spies: Molecular Machinist
Maria Spies: Molecular Machinist
Associate Professor, Biochemistry, University of Iowa, Age: 40

Lab Tools

Capturing Cancer Cells on the Move
Capturing Cancer Cells on the Move
Capturing Cancer Cells on the Move
Three approaches for isolating and characterizing rare tumor cells circulating in the bloodstream
High-Density Info
High-Density Info
High-Density Info
New developments in protein array technology

Careers

The Working Vacation
The Working Vacation
The Working Vacation
Sabbaticals are one of the perks of the academic life. They may seem daunting to implement, but the time away could prove invaluable to your career.
 

Reading Frames

Future Minded
Future Minded
Future Minded
Imagine consciousness traveling at the speed of light.

Capsule Reviews

Capsule Reviews
Capsule Reviews
Capsule Reviews
Cancer Virus, A Window on Eternity, Murderous Minds, and The Extreme Life of the Sea

Foundations

New Blood, circa 1914
New Blood, circa 1914
New Blood, circa 1914
World War I provided testing grounds for novel blood-transfusion techniques.