Features
Top 10 Innovations 2014
A Race Against Extinction
Special Section
Validating Antibodies: An Urgent Need
Highlights from a webinar held by The Scientist to discuss the role of antibody validation and cataloging in improving data reproducibility
Capsule Reviews
Capsule Reviews
Your Atomic Self, Eureka!, A Talent for Friendship, and Undeniable
Lab Tools
Cutting the Wire
Optical techniques for monitoring action potentials
Sorting Made Simpler
A guide to affordable, compact fluorescence-activated cell sorters
Notebook
Along Came a Spider
Researchers are turning to venom peptides to protect crops from their most devastating pests.
Homo Minutus
A miniature platform with multiple organ-on-a-chip constructs aims to speed up drug discovery—and create better transplants for patients.
Microflora for Hire
The guts of cows and termites harbor microbes that are renowned complex-carbohydrate digesters, but the human gastrointestinal tract has flora that just might measure up.
A New Breed
Genomics and advanced reproductive technologies have turned cattle breeding into a whole new animal.
Critic at Large
Loaded Words
As new technologies emerge, we must choose our words for them with care: names can negatively bias the inevitable debates over the ethics of scientific advances.
Incentivizing Breakthroughs
With scientific funding on shaky ground, big-dollar competitions offer a new way for life-science innovators to bring their ideas to fruition.
Modus Operandi
Bespoke Cell Jackets
Scientists make hydrogel coats for individual cells that can be tailored to specific research questions.
The Literature
Cadherin Connection
A multitasking plasma membrane protein coordinates cell division and energy metabolism in healthy—and perhaps also cancerous—Drosophila cells.
Polymerase Pieces
Researchers discover a new subunit of a bacterial RNA polymerase—as well as hints of its potential role in defending against viruses.
Nuclear Pore QA
A known membrane-remodeling complex earns a newly identified role as a quality-assurance director during the assembly of nuclear pores.
Profiles
All Systems Go
Alan Aderem earned his PhD while under house arrest for protesting apartheid in South Africa. His early political involvement has guided his scientific focus, encouraging fellow systems biologists to study immunology and infectious diseases.
Scientist to Watch
Viviana Gradinaru: Clearing the Way
Assistant Professor, Department of Biology and Biological Engineering, Caltech. Age: 33
Foundations
A Cellar’s Cellular Treasure, 1992
A spring cleaning led to the rediscovery of Theodor Boveri’s microscope slides, presumed lost during World War II.
Reading Frames
The Cellular Revolution
Early life-forms started engaging in planet-altering biological innovation more than a half billion years ago.
Bio Business
Cannabis Biotech
As medical marijuana businesses set up shop across the U.S., a handful of companies are taking the pharmaceutical route, guiding cannabis-derived drugs through clinical trials.
Editorial
Bad Raps
Understanding animal diseases—for their sake and for ours
Speaking of Science
Speaking of Science
December 2014's selection of notable quotes
Cover Story
Lurking in the Shadows
Bats harbor diverse pathogens, including Ebola, Marburg, SARS, and MERS viruses. Understanding why could help researchers stymie deadly emerging diseases.
Contributors
Contributors
Meet some of the people featured in the December 2014 issue of The Scientist.