Malaria Parasites’ Biological Clocks Coordinate Cell Destruction

Two studies show that Plasmodium—the genus of protozoans that cause malaria—have an internal sense of time that synchronizes with their host’s circadian rhythms and allows the parasites to collectively attack blood cells.

Written byAbby Olena, PhD
| 3 min read

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ABOVE: An artist’s rendering of red blood cells infected with Plasmodium.
© ISTOCK.COM, DR_MICROBE

During a malaria infection, countless Plasmodium parasites simultaneously destroy the red blood cells they’ve inhabited. This destruction causes a wave of fever and chills in the infected person that happens predictably every 24, 48, or 72 hours, depending upon which strain of the parasite is causing the infection.

For years, scientists have hypothesized that the host’s biological rhythms were responsible for the coordination and timing of the actions of Plasmodium. But in two studies published in Science today (May 14), researchers reveal that the parasites have their own inherent clock that both responds to the host and is capable of oscillating on its own.

“There’s been a longstanding question in the field as to why it is that malaria parasites are synchronous inside mammalian hosts. Is it because of the host or is it because of the ...

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Meet the Author

  • abby olena

    As a freelancer for The Scientist, Abby reports on new developments in life science for the website. She has a PhD from Vanderbilt University and got her start in science journalism as the Chicago Tribune’s AAAS Mass Media Fellow in 2013. Following a stint as an intern for The Scientist, Abby was a postdoc in science communication at Duke University, where she developed and taught courses to help scientists share their research. In addition to her work as a science journalist, she leads science writing and communication workshops and co-produces a conversational podcast. She is based in Alabama.  

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