Mouse Brains Appear to Eavesdrop on Their Fat

For the first time, a team visualizes sensory nerves projecting into adipose tissue in mice and finds these neuronal cells may counteract the local effects of the sympathetic nervous system.

Written byAlejandra Manjarrez, PhD
| 4 min read
Adipose tissue under the microscope appearing as red blobs on a white background
Register for free to listen to this article
Listen with Speechify
0:00
4:00
Share

Brain and fat are well acquainted with each other. We know, for example, that fat cells secrete hormones that signal the brain when to stop eating. This exchange of messages can be rather slow, though, as it takes time for hormones to travel from fat into the bloodstream to the brain.

A study published August 31 in Nature, however, suggests that fat may be sending much faster messages to the brain. The work provides evidence that somatosensory cells—the ones that warn us if something is cold or painful—innervate the adipose tissue of mice, hinting that these neurons may sense something in the fat, potentially prompting a reaction as fast as jerking a hand away from a hot stovetop. But what that something might be, and its effects on the brain, remain unknown for now.

This is a “really nice paper,” says University of Oxford neuroscientist Ana Domingos, who was not ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • alejandra manjarrez

    Alejandra Manjarrez is a freelance science journalist who contributes to The Scientist. She has a PhD in systems biology from ETH Zurich and a master’s in molecular biology from Utrecht University. After years studying bacteria in a lab, she now spends most of her days reading, writing, and hunting science stories, either while traveling or visiting random libraries around the world. Her work has also appeared in Hakai, The Atlantic, and Lab Times.

    View Full Profile
Share
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Eppendorf Logo

Research on rewiring neural circuit in fruit flies wins 2025 Eppendorf & Science Prize

Evident Logo

EVIDENT's New FLUOVIEW FV5000 Redefines the Boundaries of Confocal and Multiphoton Imaging

Evident Logo

EVIDENT Launches Sixth Annual Image of the Year Contest

10x Genomics Logo

10x Genomics Launches the Next Generation of Chromium Flex to Empower Scientists to Massively Scale Single Cell Research